The plasma concentration of high-density lipoprotein cholesterol (HDL-C) is inversely correlated with the incidence of atherosclerotic vascular events. In the present study we evaluated preintrusive atherosclerosis in subjects with plasma HDL-C at the extremities of normal distribution. Fifty-five subjects with primary hypoalphalipoproteinemia (HypoALP) or hyperalphalipoproteinemia (HyperALP) were compared with fifty-five control subjects with average HDL-C levels, matched for sex, age and plasma cholesterol. The average and maximal intima-media thickness (Avg-IMT and Max-IMT) of 48 carotid segments for each subject were approximately 40% greater in HypoALP than control subjects (0.94±0.06 vs. 0.69±0.04 mm, p=0.004; and 1.86±0.16 vs. 1.35±0.10 mm, p=0.025). The IMT values in HyperALP subjects (Avg-IMT: 0.71±0.04 and 1.38±0.14 mm) were the same as controls. In a large cohort of hyperlipidemic subjects (n=559), significantly greater Avg-IMT and Max-IMT were found in subjects belonging to the first HDL-C quintile (< 42 mg/dl) than all the others. The measurement of carotid IMT in cases with HypoALP and HyperALP, and in a large series of hyperlipidemic patients, thus indicates that a low HDL-C is associated with significant preintrusive atherosclerosis, while a HDL-C above average values does not lead to a further reduction of arterial wall thickening.

Increased carotid artery intima-media thickness in subjects with primary hypoalphalipoproteinemia / D. Baldassarre, M. Amato, L. Pustina, E. Tremoli, C. Sirtori, L. Calabresi, G. Franceschini. - In: ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY. - ISSN 1079-5642. - 22:2(2002), pp. 317-322.

Increased carotid artery intima-media thickness in subjects with primary hypoalphalipoproteinemia

D. Baldassarre
Primo
;
E. Tremoli;C. Sirtori;L. Calabresi
Penultimo
;
G. Franceschini
Ultimo
2002

Abstract

The plasma concentration of high-density lipoprotein cholesterol (HDL-C) is inversely correlated with the incidence of atherosclerotic vascular events. In the present study we evaluated preintrusive atherosclerosis in subjects with plasma HDL-C at the extremities of normal distribution. Fifty-five subjects with primary hypoalphalipoproteinemia (HypoALP) or hyperalphalipoproteinemia (HyperALP) were compared with fifty-five control subjects with average HDL-C levels, matched for sex, age and plasma cholesterol. The average and maximal intima-media thickness (Avg-IMT and Max-IMT) of 48 carotid segments for each subject were approximately 40% greater in HypoALP than control subjects (0.94±0.06 vs. 0.69±0.04 mm, p=0.004; and 1.86±0.16 vs. 1.35±0.10 mm, p=0.025). The IMT values in HyperALP subjects (Avg-IMT: 0.71±0.04 and 1.38±0.14 mm) were the same as controls. In a large cohort of hyperlipidemic subjects (n=559), significantly greater Avg-IMT and Max-IMT were found in subjects belonging to the first HDL-C quintile (< 42 mg/dl) than all the others. The measurement of carotid IMT in cases with HypoALP and HyperALP, and in a large series of hyperlipidemic patients, thus indicates that a low HDL-C is associated with significant preintrusive atherosclerosis, while a HDL-C above average values does not lead to a further reduction of arterial wall thickening.
Intima-media thickness, high-density lipoproteins, hypoalphalipoproteinemia, hyperalphalipoproteinemia, preintrusive atherosclerosis
Settore BIO/14 - Farmacologia
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/181824
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