The presence and possible role of androgen-metabolizing enzymes in androgen-independent prostate carcinoma (CaP) are still unclear. The aim of the present study was: 1) to evaluate the pattern of androgen metabolism (relative production of 5alpha-reduced vs. 17-keto androgens); and 2) to analyze whether one or both the two known 5alpha-reductase isoforms (5alpha-R1 and 5alpha-R2) and the aromatase (Aro) are expressed and active in this pathology.

5alpha-reductase isozymes and aromatase are differentially expressed and active in the androgen-independent human prostate cancer cell lines DU145 and PC3 / P. Negri-Cesi, A. Colciago, A. Poletti, M. Motta. - In: THE PROSTATE. - ISSN 0270-4137. - 41:4(1999 Dec 01), pp. 224-232. [10.1002/(SICI)1097-0045(19991201)41:4<224::AID-PROS2>3.0.CO;2-Q]

5alpha-reductase isozymes and aromatase are differentially expressed and active in the androgen-independent human prostate cancer cell lines DU145 and PC3

P. Negri-Cesi
Primo
;
A. Colciago
Secondo
;
A. Poletti
Penultimo
;
M. Motta
Ultimo
1999

Abstract

The presence and possible role of androgen-metabolizing enzymes in androgen-independent prostate carcinoma (CaP) are still unclear. The aim of the present study was: 1) to evaluate the pattern of androgen metabolism (relative production of 5alpha-reduced vs. 17-keto androgens); and 2) to analyze whether one or both the two known 5alpha-reductase isoforms (5alpha-R1 and 5alpha-R2) and the aromatase (Aro) are expressed and active in this pathology.
5α-reductase; Aromatase; DU145 cells; PC3 cells; Prostate cancer
Settore BIO/09 - Fisiologia
Settore BIO/13 - Biologia Applicata
Settore MED/04 - Patologia Generale
Article (author)
File in questo prodotto:
File Dimensione Formato  
Prostate 1999.pdf

accesso riservato

Tipologia: Publisher's version/PDF
Dimensione 248.93 kB
Formato Adobe PDF
248.93 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/181821
Citazioni
  • ???jsp.display-item.citation.pmc??? 6
  • Scopus 44
  • ???jsp.display-item.citation.isi??? 40
social impact