In the attempt to further characterize the role of the GABA-ergic system on morphine analgesia, nipecotic acid and guvacine, inhibitors of GABA reuptake, were administered intraventricularly in rats pretreated with morphine. Under these conditions the animals showed a decreased response to the antinociceptive effect of morphine when compared to control rats.
Nipecotic acid and guvacine antagonism on morphine analgesia in rats / P. Mantegazza, R. Tammiso, L. Vicentini, F. Zambotti, N. Zonta. - In: PHARMACOLOGICAL RESEARCH COMMUNICATIONS. - ISSN 0031-6989. - 11:8(1979 Sep), pp. 657-662.
Nipecotic acid and guvacine antagonism on morphine analgesia in rats
L. Vicentini;
1979
Abstract
In the attempt to further characterize the role of the GABA-ergic system on morphine analgesia, nipecotic acid and guvacine, inhibitors of GABA reuptake, were administered intraventricularly in rats pretreated with morphine. Under these conditions the animals showed a decreased response to the antinociceptive effect of morphine when compared to control rats.
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