1 Muscimol, a gamma-aminobutyric acid (GABA) receptor agonist, when injected intraventricularly antagonizes the antinociceptive effect of morphine given either subcutaneously or intraventricularly. The antagonistic effect of muscimol on morphine analgesia appears to be linearly related. 2 This finding provides support for the view that a GABA-ergic system is involved in morphine analgesia.

Muscimol antagonism of morphine analgesia in rats / P. Mantegazza, R. Tammiso, L. Vicentini, F. Zambotti, N. Zonta. - In: BRITISH JOURNAL OF PHARMACOLOGY. - ISSN 0007-1188. - 67:1(1979 Sep), pp. 103-107.

Muscimol antagonism of morphine analgesia in rats

L. Vicentini;
1979-09

Abstract

1 Muscimol, a gamma-aminobutyric acid (GABA) receptor agonist, when injected intraventricularly antagonizes the antinociceptive effect of morphine given either subcutaneously or intraventricularly. The antagonistic effect of muscimol on morphine analgesia appears to be linearly related. 2 This finding provides support for the view that a GABA-ergic system is involved in morphine analgesia.
Rats; Morphine; Animals; Oxazoles; Muscimol; Injections, Subcutaneous; Time Factors; Male; Reaction Time; Injections, Intraventricular
Settore BIO/14 - Farmacologia
Article (author)
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/181800
Citazioni
  • ???jsp.display-item.citation.pmc??? 5
  • Scopus 55
  • ???jsp.display-item.citation.isi??? ND
social impact