1 Muscimol, a gamma-aminobutyric acid (GABA) receptor agonist, when injected intraventricularly antagonizes the antinociceptive effect of morphine given either subcutaneously or intraventricularly. The antagonistic effect of muscimol on morphine analgesia appears to be linearly related. 2 This finding provides support for the view that a GABA-ergic system is involved in morphine analgesia.
Muscimol antagonism of morphine analgesia in rats / P. Mantegazza, R. Tammiso, L. Vicentini, F. Zambotti, N. Zonta. - In: BRITISH JOURNAL OF PHARMACOLOGY. - ISSN 0007-1188. - 67:1(1979 Sep), pp. 103-107.
Muscimol antagonism of morphine analgesia in rats
L. Vicentini;
1979-09
Abstract
1 Muscimol, a gamma-aminobutyric acid (GABA) receptor agonist, when injected intraventricularly antagonizes the antinociceptive effect of morphine given either subcutaneously or intraventricularly. The antagonistic effect of muscimol on morphine analgesia appears to be linearly related. 2 This finding provides support for the view that a GABA-ergic system is involved in morphine analgesia.
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