1 Mazindol is a new anorexigenic agent which possesses a different chemical structure from that of phenylethylamines, but shows a pharmacological profile similar to that of (+)-amphetamine. 2 Mazindol neither altered whole brain monoamine levels (noradrenaline (NA), dopamine, 5-hydroxytryptamine (5-HT)) nor changed NA levels in the hypothalamus or dopamine levels in the caudate nucleus. 3 Mazindol enhanced dopamine turnover rate in the caudate nucleus, as shown by the increased rate of dopamine decline after blockade of catecholamine synthesis by alpha-methyl-p-tyrosine and decreased the conversion index of (3H)-tyrosine into brain NA. 4 Mazindol administration did not modify pargyline-induced decline of 5-hydroxyindoleacetic acid suggesting that 5-HT turnover is not altered by this drug.
|Titolo:||Effects of mazindol, a non-phenylethylamine anorexigenic agent, on biogenic amine levels and turnover rate|
|Autori interni:||VICENTINI, LUCIA (Penultimo)|
CARRUBA, MICHELE (Primo)
|Parole Chiave:||Animals; Hydroxyindoleacetic Acid; Brain Chemistry; Caudate Nucleus; Corpus Striatum; Serotonin; Rats; Methyltyrosines; Indoles; Dopamine; Pargyline; Kinetics; Mazindol; Norepinephrine; Biogenic Amines; Male|
|Settore Scientifico Disciplinare:||Settore BIO/14 - Farmacologia|
|Data di pubblicazione:||apr-1976|
|Appare nelle tipologie:||01 - Articolo su periodico|