1 Mazindol is a new anorexigenic agent which possesses a different chemical structure from that of phenylethylamines, but shows a pharmacological profile similar to that of (+)-amphetamine. 2 Mazindol neither altered whole brain monoamine levels (noradrenaline (NA), dopamine, 5-hydroxytryptamine (5-HT)) nor changed NA levels in the hypothalamus or dopamine levels in the caudate nucleus. 3 Mazindol enhanced dopamine turnover rate in the caudate nucleus, as shown by the increased rate of dopamine decline after blockade of catecholamine synthesis by alpha-methyl-p-tyrosine and decreased the conversion index of (3H)-tyrosine into brain NA. 4 Mazindol administration did not modify pargyline-induced decline of 5-hydroxyindoleacetic acid suggesting that 5-HT turnover is not altered by this drug.

Effects of mazindol, a non-phenylethylamine anorexigenic agent, on biogenic amine levels and turnover rate / M. O. Carruba, A. Groppetti, P. Mantegazza, L. Vicentini, F. Zambotti. - In: BRITISH JOURNAL OF PHARMACOLOGY. - ISSN 0007-1188. - 56:4(1976 Apr), pp. 431-436. [10.1111/j.1476-5381.1976.tb07454.x]

Effects of mazindol, a non-phenylethylamine anorexigenic agent, on biogenic amine levels and turnover rate

M.O. Carruba
Primo
;
L. Vicentini
Penultimo
;
1976

Abstract

1 Mazindol is a new anorexigenic agent which possesses a different chemical structure from that of phenylethylamines, but shows a pharmacological profile similar to that of (+)-amphetamine. 2 Mazindol neither altered whole brain monoamine levels (noradrenaline (NA), dopamine, 5-hydroxytryptamine (5-HT)) nor changed NA levels in the hypothalamus or dopamine levels in the caudate nucleus. 3 Mazindol enhanced dopamine turnover rate in the caudate nucleus, as shown by the increased rate of dopamine decline after blockade of catecholamine synthesis by alpha-methyl-p-tyrosine and decreased the conversion index of (3H)-tyrosine into brain NA. 4 Mazindol administration did not modify pargyline-induced decline of 5-hydroxyindoleacetic acid suggesting that 5-HT turnover is not altered by this drug.
Animals; Hydroxyindoleacetic Acid; Brain Chemistry; Caudate Nucleus; Corpus Striatum; Serotonin; Rats; Methyltyrosines; Indoles; Dopamine; Pargyline; Kinetics; Mazindol; Norepinephrine; Biogenic Amines; Male
Settore BIO/14 - Farmacologia
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/181768
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