Mazindol, a new anorexigenic agent which possesses a different chemical structure from phenylethylamine derivatives such as amphetamine, causes anorexia along with increases in locomotor activity and body temperature. Mazindol also induces stereotyped behaviour and, if injected into rats with unilateral nigro-striatal lesions, causes turning towards the lesioned side. Mazindol-induced anorexia is antagonized by pretreatment with alpha-methyl-p-tyrosine or pimozide. Pimozide pretreatment prevents the rotation induced by Mazindol in rats with unilateral nigro-striatal lesions. The involvement of dopamine in the mechanism whereby Mazindol elicits anorexia and turning behaviour is discussed.
|Titolo:||Behavioural effects of a new non-phenylethylamine anorexigenic agent: mazindol|
CARRUBA, MICHELE (Secondo)
|Parole Chiave:||Animals; Humans; Stereotyped Behavior; Appetite; Behavior, Animal; Methyltyrosines; Rats; Indoles; Body Temperature; Dextroamphetamine; Mazindol; Motor Activity; Pimozide; Male|
|Settore Scientifico Disciplinare:||Settore BIO/14 - Farmacologia|
|Data di pubblicazione:||apr-1976|
|Digital Object Identifier (DOI):||10.1016/0014-2999(76)90089-3|
|Appare nelle tipologie:||01 - Articolo su periodico|