Systemic administration of parachlorophenylalanine (PCPA, 100 mg/kg sc on alternate days X two times), a blocker of serotonin (5-HT) synthesis, considerably decreased brain 5-HT and plasma prolactin (PRL) levels in young male rats. Intraventricular (IVT) administration of 5,7-dihydroxytryptamine (5,7-DHT, 200 mug/20 mul), a neurotoxic drug which destroys 5-HT nerve terminals, induced, 3, 12, and 30 days after treatment, a marked depletion of brain 5-HT and 5-hydroxyindoleacetic acid (5-HIAA) and considerably reduced plasma PRL levels at each time interval. Feeding of rat for up to 4 days with a tryptophan (TP)-deficient diet, caused a depletion of brain 5-HT and 5-HIAA contents and did not modify plasma PRL levels. Addition of TP (2 g/kg of diet) to the TP-deficient diet resulted in increased brain 5-HT and 5-HIAA contents and significantly increased PRL levels. These data provide evidence for the role of the 5-HT system in the maintenance of tonic PRL secretion.
|Titolo:||Stimulatory role for brain serotoninergic system on prolactin secretion in the male rat|
VICENTINI, LUCIA (Penultimo)
|Parole Chiave:||Animals; Tryptophan; Age Factors; Hydroxyindoleacetic Acid; Brain; Desipramine; Serotonin; Prolactin; Rats; 5,6-Dihydroxytryptamine; Fenclonine; Norepinephrine; Male|
|Settore Scientifico Disciplinare:||Settore BIO/14 - Farmacologia|
|Data di pubblicazione:||mar-1976|
|Digital Object Identifier (DOI):||10.3181/00379727-151-39247|
|Appare nelle tipologie:||01 - Articolo su periodico|