Male Swiss albino mice (CD-1) were given single doses of [14C]carmoisine by stomach tube (200 mg/kg, 6 μCi) or iv injection (200 mg/kg; 0.7 μCi). The plasma and tissue kinetics of the compound were studied by monitoring the decay of radioactivity in the plasma, gastro-intestinal tract, liver, kidney, lung, testes, spleen and gall bladder. The feces and urine of mice placed in individual metabolism cages were collected between 4 and 96 hr after dosing. After oral administration, peak levels of radioactivity occurred in the plasma and the liver, lungs, testes and spleen 8 hr after dosing. Radioactivity was almost completely (98%) excreted in the feces and urine within 16-32 hr after oral dosing. The plasma [14C]radioactivity decay curve after iv administration indicated a very rapid distribution of the compound into the tissues (t(1/2)=10 min) and an efficient excretion, mostly through the gastro-intestinal tract (92%), which was complete 48 hr after dosing.

Absorption, distribution and excretion of [14C]carmoisine in mice after oral and intravenous administration / C.L. Galli, M. Marinovich, L.G. Costa. - In: FOOD AND COSMETICS TOXICOLOGY. - ISSN 0015-6264. - 19:4(1981 Aug), pp. 413-418. [10.1016/0015-6264(81)90443-0]

Absorption, distribution and excretion of [14C]carmoisine in mice after oral and intravenous administration

C.L. Galli
Primo
;
M. Marinovich
Secondo
;
1981

Abstract

Male Swiss albino mice (CD-1) were given single doses of [14C]carmoisine by stomach tube (200 mg/kg, 6 μCi) or iv injection (200 mg/kg; 0.7 μCi). The plasma and tissue kinetics of the compound were studied by monitoring the decay of radioactivity in the plasma, gastro-intestinal tract, liver, kidney, lung, testes, spleen and gall bladder. The feces and urine of mice placed in individual metabolism cages were collected between 4 and 96 hr after dosing. After oral administration, peak levels of radioactivity occurred in the plasma and the liver, lungs, testes and spleen 8 hr after dosing. Radioactivity was almost completely (98%) excreted in the feces and urine within 16-32 hr after oral dosing. The plasma [14C]radioactivity decay curve after iv administration indicated a very rapid distribution of the compound into the tissues (t(1/2)=10 min) and an efficient excretion, mostly through the gastro-intestinal tract (92%), which was complete 48 hr after dosing.
Settore BIO/14 - Farmacologia
http://www.ncbi.nlm.nih.gov/pubmed?term=Absorption%2C%20distribution%20and%20excretion%20of%20[14C]carmoisine%20in%20mice%20after%20oral%20and%20intravenous%20administration
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/181738
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