Mantle-cell lymphoma (MCL) is a B-cell tumour with a usually poor prognosis, characterized by the proliferation of small cleaved lymphocytes with a diffuse growth pattern. We report a polymerase chain reaction-based analysis of minimal residual disease in a patient who achieved complete remission after allogeneic blood cell transplantation (BCT). Rearrangement of the immunoglobulin heavy-chain genes was used to generate a lymphoma-specific molecular marker. Lymphoma cells were not detectable in a bone marrow sample collected 12 months after BCT. Our findings suggest that allogeneic BCT may offer a curative approach to MCL.

Clinical and molecular remission after allogeneic blood cell transplantation in a patient with mantle-cell lymphoma / P. Corradini, M. Ladetto, M. Astolfi, C. Voena, C. Tarella, A. Bacigalupo, A. Pileri. - In: BRITISH JOURNAL OF HAEMATOLOGY. - ISSN 0007-1048. - 94:2(1996 Aug), pp. 376-8-378. [10.1046/j.1365-2141.1996.d01-1816.x]

Clinical and molecular remission after allogeneic blood cell transplantation in a patient with mantle-cell lymphoma

P. Corradini
Primo
;
C. Tarella;
1996

Abstract

Mantle-cell lymphoma (MCL) is a B-cell tumour with a usually poor prognosis, characterized by the proliferation of small cleaved lymphocytes with a diffuse growth pattern. We report a polymerase chain reaction-based analysis of minimal residual disease in a patient who achieved complete remission after allogeneic blood cell transplantation (BCT). Rearrangement of the immunoglobulin heavy-chain genes was used to generate a lymphoma-specific molecular marker. Lymphoma cells were not detectable in a bone marrow sample collected 12 months after BCT. Our findings suggest that allogeneic BCT may offer a curative approach to MCL.
Neoplasm, Residual; Polymerase Chain Reaction; Humans; Adult; Blood Component Transfusion; Pilot Projects; Transplantation, Homologous; Lymphoma, Non-Hodgkin; Male; Remission Induction
Settore MED/15 - Malattie del Sangue
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/181722
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