Mantle-cell lymphoma (MCL) is a B-cell tumour with a usually poor prognosis, characterized by the proliferation of small cleaved lymphocytes with a diffuse growth pattern. We report a polymerase chain reaction-based analysis of minimal residual disease in a patient who achieved complete remission after allogeneic blood cell transplantation (BCT). Rearrangement of the immunoglobulin heavy-chain genes was used to generate a lymphoma-specific molecular marker. Lymphoma cells were not detectable in a bone marrow sample collected 12 months after BCT. Our findings suggest that allogeneic BCT may offer a curative approach to MCL.
|Titolo:||Clinical and molecular remission after allogeneic blood cell transplantation in a patient with mantle-cell lymphoma|
CORRADINI, PAOLO (Primo)
|Parole Chiave:||Neoplasm, Residual; Polymerase Chain Reaction; Humans; Adult; Blood Component Transfusion; Pilot Projects; Transplantation, Homologous; Lymphoma, Non-Hodgkin; Male; Remission Induction|
|Settore Scientifico Disciplinare:||Settore MED/15 - Malattie del Sangue|
|Data di pubblicazione:||ago-1996|
|Digital Object Identifier (DOI):||10.1046/j.1365-2141.1996.d01-1816.x|
|Appare nelle tipologie:||01 - Articolo su periodico|