Hypoalphalipoproteinemia can result from defects in the genes encoding apolipoprotein A-I, the major protein component of HDL, or enzymes that are critical for the formation/maturation of mature HDL. Recent information contradicts earlier findings, suggesting that most of the affected subjects are at increased risk of developing coronary heart disease, independent of the mutated gene. A possible exception is represented by mutations in the apolipoprotein A-I gene leading to structural variants, that might even exert a protective effect against atherosclerosis.

High density lipoprotein and coronary heart disease: insights from mutations leading to low high density lipoprotein / L. Calabresi, G. Franceschini. - In: CURRENT OPINION IN LIPIDOLOGY. - ISSN 0957-9672. - 8:4(1997), pp. 219-224.

High density lipoprotein and coronary heart disease: insights from mutations leading to low high density lipoprotein

L. Calabresi
Primo
;
G. Franceschini
Ultimo
1997

Abstract

Hypoalphalipoproteinemia can result from defects in the genes encoding apolipoprotein A-I, the major protein component of HDL, or enzymes that are critical for the formation/maturation of mature HDL. Recent information contradicts earlier findings, suggesting that most of the affected subjects are at increased risk of developing coronary heart disease, independent of the mutated gene. A possible exception is represented by mutations in the apolipoprotein A-I gene leading to structural variants, that might even exert a protective effect against atherosclerosis.
Settore BIO/14 - Farmacologia
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/181711
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