Tetraconazole, a new, recently introduced antifungal triazole, has been assayed in parallel with a number of standard analogues on various sensitive strains of Ustilago maydis. The values of EC50 and EC90 tetraconazole concentrations, determined on strain ATCC 14826 in agar, were 0.5 × 10-6 and 3.5 × 10-5 m, respectively, in reasonable agreement with those needed to inhibit by 50% and 90%, respectively, the ergosterol biosynthesis in broth cultures. Squalene and 12 sterols have been extracted from the latter, characterized and quantified. Accumulation of 14α-methylsterols and reduction of ergosterol and other late precursors are consistent with the inhibition of 14α-demethylase caused by the title compound.

Comparative antifungal effect and mode of action of tetraconazole on Ustilago maydis / R. Carzaniga, A. Carelli, G. Farina, A. Arnoldi, F. Gozzo. - In: PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY. - ISSN 0048-3575. - 40:3(1991), pp. 274-283.

Comparative antifungal effect and mode of action of tetraconazole on Ustilago maydis

G. Farina;A. Arnoldi
Penultimo
;
1991

Abstract

Tetraconazole, a new, recently introduced antifungal triazole, has been assayed in parallel with a number of standard analogues on various sensitive strains of Ustilago maydis. The values of EC50 and EC90 tetraconazole concentrations, determined on strain ATCC 14826 in agar, were 0.5 × 10-6 and 3.5 × 10-5 m, respectively, in reasonable agreement with those needed to inhibit by 50% and 90%, respectively, the ergosterol biosynthesis in broth cultures. Squalene and 12 sterols have been extracted from the latter, characterized and quantified. Accumulation of 14α-methylsterols and reduction of ergosterol and other late precursors are consistent with the inhibition of 14α-demethylase caused by the title compound.
Settore CHIM/10 - Chimica degli Alimenti
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/181677
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