The stereoselective synthesis of two precursors of tricyclic beta-lactam antibiotics (trinems) has been attempted by a novel approach that involves a highly stereoselective azetidinone ring-forming reaction followed by the reduction of a functionalized aromatic substituent at C-4 of the beta-lactam nucleus.

A novel approach to the synthesis of precursors of tricyclic beta-lactam antibiotics / R. Annunziata, M. Benaglia, M. Cinquini, F. Cozzi, L. Poletti, L. Raimondi, A. Perboni. - In: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY. - ISSN 1434-193X. - 1999:11(1999), pp. 3067-3072. [10.1002/(sici)1099-0690(199911)1999:11<3067::aid-ejoc3067>3.0.co;2-k]

A novel approach to the synthesis of precursors of tricyclic beta-lactam antibiotics

R. Annunziata
Primo
;
M. Benaglia
Secondo
;
M. Cinquini;F. Cozzi;L. Poletti;L. Raimondi
Penultimo
;
1999

Abstract

The stereoselective synthesis of two precursors of tricyclic beta-lactam antibiotics (trinems) has been attempted by a novel approach that involves a highly stereoselective azetidinone ring-forming reaction followed by the reduction of a functionalized aromatic substituent at C-4 of the beta-lactam nucleus.
thioester; enolate; imine; lactams; asymmetric synthesis
Settore CHIM/06 - Chimica Organica
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/181636
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