Abnormalities in the cyclic adenosine monophosphate (cAMP)-dependent phosphorylation system have been recently reported in patients with bipolar disorder. We evaluated the immunoreactivity of the regulatory and catalytic subunits of cAMP-dependent protein kinase (protein kinase A) and 1 of its substrates, Rap1, in platelets from untreated euthymic, manic, and depressed patients with bipolar disorder and healthy subjects.
|Titolo:||Abnormalities of cyclic adenosine monophosphate signaling in platelets from untreated patients with bipolar disorder|
TARDITO, DANIELA (Secondo)
|Parole Chiave:||Bipolar disorder; platelets; Rap1; protein kinase A|
|Settore Scientifico Disciplinare:||Settore BIO/14 - Farmacologia|
|Data di pubblicazione:||mar-1999|
|Appare nelle tipologie:||01 - Articolo su periodico|