Abnormalities in the cyclic adenosine monophosphate (cAMP)-dependent phosphorylation system have been recently reported in patients with bipolar disorder. We evaluated the immunoreactivity of the regulatory and catalytic subunits of cAMP-dependent protein kinase (protein kinase A) and 1 of its substrates, Rap1, in platelets from untreated euthymic, manic, and depressed patients with bipolar disorder and healthy subjects.

Abnormalities of cyclic adenosine monophosphate signaling in platelets from untreated patients with bipolar disorder / J. Perez, D. Tardito, S. Mori, G. Racagni, E. Smeraldi, R. Zanardi. - In: ARCHIVES OF GENERAL PSYCHIATRY. - ISSN 0003-990X. - 56:3(1999 Mar), pp. 248-253.

Abnormalities of cyclic adenosine monophosphate signaling in platelets from untreated patients with bipolar disorder

D. Tardito;G. Racagni;
1999-03

Abstract

Abnormalities in the cyclic adenosine monophosphate (cAMP)-dependent phosphorylation system have been recently reported in patients with bipolar disorder. We evaluated the immunoreactivity of the regulatory and catalytic subunits of cAMP-dependent protein kinase (protein kinase A) and 1 of its substrates, Rap1, in platelets from untreated euthymic, manic, and depressed patients with bipolar disorder and healthy subjects.
Bipolar disorder; platelets; Rap1; protein kinase A
Settore BIO/14 - Farmacologia
ARCHIVES OF GENERAL PSYCHIATRY
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/181622
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