Karyotype analysis was performed on successive cultures of fibroblasts from the parents of two trisomic 21 patients. Starting from the 7th passage in the father cultures an aneuploid clone showing an extra E-like chromosome was found, which eventually overgrew the cell population. The significance of this cytogenetic finding is discussed in relation to the recurrence of the trisomy in the family.

Detection of aneuploid cells in fibroblast cultures from the father of two trisomy 21 patients / G. Simoni, A. Mottura, M. Stefanini, L. Larizza, P. Maraschio, F. Nuzzo. - In: ANNALES DE GENETIQUE. - ISSN 0003-3995. - 19:3(1976 Sep), pp. 169-71-171.

Detection of aneuploid cells in fibroblast cultures from the father of two trisomy 21 patients

G. Simoni
Primo
;
L. Larizza;
1976-09

Abstract

Karyotype analysis was performed on successive cultures of fibroblasts from the parents of two trisomic 21 patients. Starting from the 7th passage in the father cultures an aneuploid clone showing an extra E-like chromosome was found, which eventually overgrew the cell population. The significance of this cytogenetic finding is discussed in relation to the recurrence of the trisomy in the family.
Karyotyping; Aneuploidy; Cells, Cultured; Humans; Down Syndrome; Fibroblasts
Settore MED/03 - Genetica Medica
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/181602
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