To assess whether nonneoplastic Bcl-2/IgH rearrangements act as a confounding factor in the setting of minimal residual disease analysis by evaluating their incidence in a panel of lymphoma-free subjects, including cancer-free donors and chemotherapy-naive and chemotherapy-treated cancer patients.

PCR-detectable nonneoplastic Bcl-2/IgH rearrangements are common in normal subjects and cancer patients at diagnosis but rare in subjects treated with chemotherapy / M. Ladetto, D. Drandi, M. Compagno, M. Astolfi, F. Volpato, C. Voena, A. Novarino, B. Pollio, A. Addeo, I. Ricca, P. Falco, F. Cavallo, S. Vallet, P. Corradini, A. Pileri, G. Tamponi, A. Palumbo, O. Bertetto, M. Boccadoro, C. Tarella. - In: JOURNAL OF CLINICAL ONCOLOGY. - ISSN 0732-183X. - 21:7(2003 Apr 01), pp. 1398-1403.

PCR-detectable nonneoplastic Bcl-2/IgH rearrangements are common in normal subjects and cancer patients at diagnosis but rare in subjects treated with chemotherapy

P. Corradini;C. Tarella
2003

Abstract

To assess whether nonneoplastic Bcl-2/IgH rearrangements act as a confounding factor in the setting of minimal residual disease analysis by evaluating their incidence in a panel of lymphoma-free subjects, including cancer-free donors and chemotherapy-naive and chemotherapy-treated cancer patients.
Humans; Lymphoma, Follicular; Gene Rearrangement; Aged; Translocation, Genetic; Proto-Oncogene Proteins c-bcl-2; Polymerase Chain Reaction; Neoplasms; Prospective Studies; Aged, 80 and over; Adult; Middle Aged; Immunoglobulin Heavy Chains; Female; Male
Settore MED/15 - Malattie del Sangue
Article (author)
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/181523
Citazioni
  • ???jsp.display-item.citation.pmc??? 4
  • Scopus 35
  • ???jsp.display-item.citation.isi??? 30
social impact