In anaesthetized (Thiopental-sodium 15 mg/kg i.v.)tracheostomized, spontaneously breathing pigs, has been evaluated the circolatory activity of ET-1 (20-40-100 pM/kg) i.v. administered. Our results show a biphasic action of ET-1 on systemic (MAP) and pulmonary arterial pressure (MPAP)and on vascular resistances (SVR, PVR). The hypotensive effect appears 2 min after administration and it is followed by an increase of these parameters. The vasoconstriction is dose dependent and show a long-lasting activity of ET-1. Cardiac output and heart rate do not significantly change.

Variazioni emodinamiche indotte da endotelina (ET-1) nel maiale / M.G. Clement, M. Dimori, M. Albertini. - In: ATTI DELLA SOCIETA' ITALIANA DELLE SCIENZE VETERINARIE. - ISSN 1721-1980. - 46:(1992), pp. 327-330. ((Intervento presentato al 46. convegno XLVI Convegno SISVet tenutosi a Venezia - San Giuliano nel 1992.

Variazioni emodinamiche indotte da endotelina (ET-1) nel maiale

M.G. Clement
Primo
;
M. Albertini
Ultimo
1992

Abstract

In anaesthetized (Thiopental-sodium 15 mg/kg i.v.)tracheostomized, spontaneously breathing pigs, has been evaluated the circolatory activity of ET-1 (20-40-100 pM/kg) i.v. administered. Our results show a biphasic action of ET-1 on systemic (MAP) and pulmonary arterial pressure (MPAP)and on vascular resistances (SVR, PVR). The hypotensive effect appears 2 min after administration and it is followed by an increase of these parameters. The vasoconstriction is dose dependent and show a long-lasting activity of ET-1. Cardiac output and heart rate do not significantly change.
Settore VET/02 - Fisiologia Veterinaria
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/181378
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