In anaesthetized (Thiopental-sodium 15 mg/kg i.v.)tracheostomized, spontaneously breathing pigs, has been evaluated the circolatory activity of ET-1 (20-40-100 pM/kg) i.v. administered. Our results show a biphasic action of ET-1 on systemic (MAP) and pulmonary arterial pressure (MPAP)and on vascular resistances (SVR, PVR). The hypotensive effect appears 2 min after administration and it is followed by an increase of these parameters. The vasoconstriction is dose dependent and show a long-lasting activity of ET-1. Cardiac output and heart rate do not significantly change.
Variazioni emodinamiche indotte da endotelina (ET-1) nel maiale / M.G. Clement, M. Dimori, M. Albertini. - In: ATTI DELLA SOCIETA' ITALIANA DELLE SCIENZE VETERINARIE. - ISSN 1721-1980. - 46:(1992), pp. 327-330. ((Intervento presentato al 46. convegno XLVI Convegno SISVet tenutosi a Venezia - San Giuliano nel 1992.
Variazioni emodinamiche indotte da endotelina (ET-1) nel maiale
M.G. ClementPrimo
;M. AlbertiniUltimo
1992
Abstract
In anaesthetized (Thiopental-sodium 15 mg/kg i.v.)tracheostomized, spontaneously breathing pigs, has been evaluated the circolatory activity of ET-1 (20-40-100 pM/kg) i.v. administered. Our results show a biphasic action of ET-1 on systemic (MAP) and pulmonary arterial pressure (MPAP)and on vascular resistances (SVR, PVR). The hypotensive effect appears 2 min after administration and it is followed by an increase of these parameters. The vasoconstriction is dose dependent and show a long-lasting activity of ET-1. Cardiac output and heart rate do not significantly change.
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