(R)- and (S)-2-methyldecan-1-ol 3a has been prepared in > 98% enantiomeric excess (ee) by transesterification with vinyl acetate in chloroform in the presence of Pseudomonas fluorescens lipase. Oxidation of the alcohol 3a affords nearly optically pure 2-methyldecanoic acid 3b.

A chemoenzymatic synthesis of enantiomerically pure (R)- and (S)-2-methyldecan-1-ol / P. Ferraboschi, P. Grisenti, A. Manzocchi, E. Santaniello. - In: JOURNAL OF THE CHEMICAL SOCIETY. PERKIN TRANSACTIONS. I. - ISSN 0300-922X. - :9(1992), pp. 1159-1161.

A chemoenzymatic synthesis of enantiomerically pure (R)- and (S)-2-methyldecan-1-ol

P. Ferraboschi
Primo
;
A. Manzocchi
Penultimo
;
E. Santaniello
Ultimo
1992

Abstract

(R)- and (S)-2-methyldecan-1-ol 3a has been prepared in > 98% enantiomeric excess (ee) by transesterification with vinyl acetate in chloroform in the presence of Pseudomonas fluorescens lipase. Oxidation of the alcohol 3a affords nearly optically pure 2-methyldecanoic acid 3b.
isoprenoid synthon; esters; derivatives; lipase; pheromone; alcohols; reagents
Settore BIO/10 - Biochimica
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/181146
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