Lipoprotein compositional studies were carried out in 20 patients with atherosclerotic peripheral vascular disease. Twelve of these patients were normolipidemic, the other eight, hypertriglyceridemic. Ten normolipidemic and 10 hypertriglyceridemic age-matched subjects were used as controls. High density lipoprotein cholesterol levels were markedly reduced in the hypertriglyceridemic subjects, both with (35.1 ± 5.0 mg/dl) and without (36.2 ± 11.7 mg/dl) peripheral vascular disease, as compared to the normolipidemic patients (47.0 ± 6.3 mg/dl) and controls (48.1 ± 10.0 mg/dl). A decreased relative content of apo C-II in very low density lipoproteins in the hypertriglyceridemic subjects, as compared to the normolipidemics, was detected by isoelectric focusing. Hypertriglyceridemia in patients with peripheral vascular disease shows a typical Type IV lipoprotein and apoprotein profile. Apoprotein B levels in very low and low density lipoproteins were determined by electroimmunodiffusion and selective precipitation with tetramethylurea (r=0.981 between the two methods). All the patients with peripheral vascular disease showed an increased apo B content in very low density lipoproteins (VLDL) as compared to controls (apo B cholesterol in VLDL = 0.431 ± 0.124 for peripheral vascular disease patients and 0.236 ± 0.086 for controls, p < 0.001). A significant correlation between VLDL cholesterol and apo B levels was detected both in peripheral vascular disease patients and in controls; however, two distinct populations could be clearly separated (slopes of the regression lines: peripheral vascular disease patients = 0.350; controls = 0.215, p < 0.001). The data suggest a possible discriminatory power of VLDL-apo B levels in patients with peripheral vascular disease independent from other lipoprotein and lipid parameters.
|Titolo:||Increased apoprotein B in very low density lipoproteins of patients with peripheral vascular disease|
|Settore Scientifico Disciplinare:||Settore BIO/14 - Farmacologia|
|Data di pubblicazione:||1982|
|Appare nelle tipologie:||01 - Articolo su periodico|