Albumin, at concentration normally present in plasma (~ 600 μM), significantly inhibited leukotriene B4 formation induced by a receptor mediated (fMet-Leu-Phe) and a receptor independent (calcium ionophore A23187) stimuli in human neutrophils. The inhibition of leukotriene B4 synthesis was accompanied by a concomitant reduction of neutrophil aggregation. In addition, this plasma protein prevented the increase in F-actin content of neutrophils stimulated with fMet-Leu-Phe and A23187, thus suppressing actin polymerization. These data indicate that albumin profoundly affects biochemical and functional aspects of neutrophils suggesting, for this plasma protein, a regulatory role in the overall pattern of the inflammatory reaction.

Inhibition of human neutrophil aggregation by albumin. Relationship with cytoskeleton reorganization / S. Colli, M. Marinovich, E. Stragliotto, C.L. Galli, E. Tremoli. - In: BIOCHEMICAL PHARMACOLOGY. - ISSN 0006-2952. - 38:22(1989), pp. 3909-3912.

Inhibition of human neutrophil aggregation by albumin. Relationship with cytoskeleton reorganization

S. Colli
Primo
;
M. Marinovich
Secondo
;
C.L. Galli
Penultimo
;
E. Tremoli
Ultimo
1989

Abstract

Albumin, at concentration normally present in plasma (~ 600 μM), significantly inhibited leukotriene B4 formation induced by a receptor mediated (fMet-Leu-Phe) and a receptor independent (calcium ionophore A23187) stimuli in human neutrophils. The inhibition of leukotriene B4 synthesis was accompanied by a concomitant reduction of neutrophil aggregation. In addition, this plasma protein prevented the increase in F-actin content of neutrophils stimulated with fMet-Leu-Phe and A23187, thus suppressing actin polymerization. These data indicate that albumin profoundly affects biochemical and functional aspects of neutrophils suggesting, for this plasma protein, a regulatory role in the overall pattern of the inflammatory reaction.
Settore BIO/14 - Farmacologia
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/181125
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