Microinjections of morphine in the rat periaqueductal gray matter (PAG) inhibited intestinal transit in linear relation to the log of the dose administered (in the range from 5 to 20 μg/rat). This linear regression was parallel with that obtained on intracerebroventricular (i.c.v.) or intraperitoneal (i.p.) administration of morphine and the intracerebral (i.c.) route was calculated to be 4 times more potent than the i.c.v. route and 189 times more potent than the i.p. route. Monolateral electrolytic lesions into the PAG abolished the intestinal effect of i.c.v. morphine to a large extent. The relevance of other brain areas and the type of opiate receptors involved in this central effect of morphine are discussed.
|Titolo:||Involvement of periaqueductal gray matter in intestinal effect of centrally administered morphine|
SALA, MARIAELVINA (Primo)
|Parole Chiave:||Intestinal transit; Morphine; Periaqueductal gray|
|Settore Scientifico Disciplinare:||Settore BIO/14 - Farmacologia|
|Data di pubblicazione:||1983|
|Digital Object Identifier (DOI):||10.1016/0014-2999(83)90473-9|
|Appare nelle tipologie:||01 - Articolo su periodico|