The feasibility and toxicity of allogeneic stem cell transplantation after nonmyeloablative conditioning including thiotepa, fludarabine, and cyclophosphamide have been investigated in 6 patients with breast cancer and 7 patients with renal cell cancer. The program included the use of escalating doses of donor lymphocyte infusions (DLI) and/or interferon alpha (IFNalpha) for patients showing no tumor response and no graft-versus-host disease (GVHD). Patients were at high risk of transplant-related mortality (TRM) because of age, advanced stage, and previous treatments. We observed a partial remission in 4 renal cancer and in 2 breast cancer patients (one at the molecular level in the bone marrow), occurring after cyclosporine withdrawal or after DLI and/or IFNalpha. All the responses were accompanied by the occurrence of acute GVHD. We conclude that reduced-intensity allogeneic stem cell transplantation is a feasible procedure in renal and breast cancer, and that the exploitation of graft-versus-tumor effect after DLI is a promising finding.
|Titolo:||Nonmyeloablative conditioning followed by hematopoietic cell allografting and donor lymphocyte infusions for patients with metastatic renal and breast cancer|
|Parole Chiave:||Humans; Nuclear Family; Breast Neoplasms; Transplantation, Homologous; Platelet Transfusion; Tissue Donors; Lymphocyte Transfusion; Kidney Neoplasms; Adult; Treatment Outcome; Hematopoietic Stem Cell Transplantation; Carcinoma, Renal Cell; Neoplasm Metastasis; Middle Aged; Adolescent; Female; Male|
|Settore Scientifico Disciplinare:||Settore MED/15 - Malattie del Sangue|
|Data di pubblicazione:||1-giu-2002|
|Digital Object Identifier (DOI):||10.1182/blood.V99.11.4234|
|Appare nelle tipologie:||01 - Articolo su periodico|