The Saccharomyces cerevisiae strain XL16-5B exhibited a fungicidal response to treatment with ketoconazole. Cell death became apparent during prolonged treatment over 72 h following an initial period over 24 h where viable cells were found and limited cell division occurred. Sterol analysis showed some differences between XL16-5B and the strain XY729-5a, which had a fungistatic response to ketoconazole. In particular, the level of ergosterol was higher in XL16-5B and remained high during treatment.
|Titolo:||Studies on azole-induced cell death inSaccharomyces cerevisiae|
ARNOLDI, ANNA (Penultimo)
|Parole Chiave:||Azole; Fungicidal; Inhibition; P450; Saccharomyces cerevisiae|
|Settore Scientifico Disciplinare:||Settore CHIM/10 - Chimica degli Alimenti|
|Data di pubblicazione:||1994|
|Digital Object Identifier (DOI):||10.1111/j.1574-6968.1994.tb06641.x|
|Appare nelle tipologie:||01 - Articolo su periodico|