The Saccharomyces cerevisiae strain XL16-5B exhibited a fungicidal response to treatment with ketoconazole. Cell death became apparent during prolonged treatment over 72 h following an initial period over 24 h where viable cells were found and limited cell division occurred. Sterol analysis showed some differences between XL16-5B and the strain XY729-5a, which had a fungistatic response to ketoconazole. In particular, the level of ergosterol was higher in XL16-5B and remained high during treatment.
Studies on azole-induced cell death inSaccharomyces cerevisiae / S. L. Kelly, S. Kenna, A. Arnoldi, D. E. Kelly. - In: FEMS MICROBIOLOGY LETTERS. - ISSN 0378-1097. - 115:2-3(1994), pp. 219-222.
Titolo: | Studies on azole-induced cell death inSaccharomyces cerevisiae |
Autori: | ARNOLDI, ANNA (Penultimo) |
Parole Chiave: | Azole; Fungicidal; Inhibition; P450; Saccharomyces cerevisiae |
Settore Scientifico Disciplinare: | Settore CHIM/10 - Chimica degli Alimenti |
Data di pubblicazione: | 1994 |
Rivista: | |
Tipologia: | Article (author) |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1111/j.1574-6968.1994.tb06641.x |
Appare nelle tipologie: | 01 - Articolo su periodico |