Rapamycin is the latest in a series of new immunosuppressants. Because of its unique capacity to inhibit lymphokine signal transduction, the immune-modulating potentials of rapamycin appear to be different from the antecedent agents, Cyclosporine and FK506. This influence on the effector arm of the immune-response makes Rapamycin a suitable candidate for multiple-drug therapy in combination with Cyclosporine which acts earlier in the immunoresponse process. Rapamycin, unlike Cyclosporine and FK506, has been shown to affect B-cell functions and T-cell - B-cell signal pathways. The effect on antibody synthesis may explain Rapamycin induced unresponsiveness.

IMMUNOPHARMACOLOGY OF RAPAMYCIN / M. Ferraresso, B. Kahan. - In: EOS. - ISSN 0392-6699. - 12:4(1992), pp. 252-255.

IMMUNOPHARMACOLOGY OF RAPAMYCIN

M. Ferraresso
Primo
;
1992

Abstract

Rapamycin is the latest in a series of new immunosuppressants. Because of its unique capacity to inhibit lymphokine signal transduction, the immune-modulating potentials of rapamycin appear to be different from the antecedent agents, Cyclosporine and FK506. This influence on the effector arm of the immune-response makes Rapamycin a suitable candidate for multiple-drug therapy in combination with Cyclosporine which acts earlier in the immunoresponse process. Rapamycin, unlike Cyclosporine and FK506, has been shown to affect B-cell functions and T-cell - B-cell signal pathways. The effect on antibody synthesis may explain Rapamycin induced unresponsiveness.
Settore MED/18 - Chirurgia Generale
EOS
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/180623
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