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EnglishBackground and Aims: Allergic rhinitis is characterized by eosinophil infiltration and accumulation in the nasal mucosa mainly due to IL-3, IL-5, and eotaxin activities. We undertook this study to investigate a possible in vivo effect of carbon dioxide-enriched water inhalation in patients with allergic rhinitis. Methods: Twenty five consecutive patients inhaled carbon dioxide-enriched water at Fonti di Rabbi Spa Centre (Trento, Italy). Symptom scores for nasal obstruction, itching and sneezing were obtained before and after treatment. Nasal lavage was collected, and IL-3, IL-5, and eotaxin levels were assessed using the quantitative sandwich enzyme immunoassay technique. Cytometric analysis was performed on samples to measure total cell count, CD45+ cells, and percentages of polymorphonucleates and lymphocytes. Results: There were statistically significant differences in chemokine levels and in cell populations between patients and healthy controls before treatment. After carbon dioxide-enriched water inhalation, we observed statistically significant improvements in symptom scores, chemokine levels, and percentages of cell populations. Conclusions: Our results seem to confirm the role of IL-3, IL-5, and eotaxin in the pathophysiology of allergy and the beneficial effect of carbon dioxide-enriched water inhalation in patients affected by allergic rhinitis.
Carbon dioxide-enriched water inhalation in patients with allergic rhinitis and its relationship with nasal fluid cytokine/chemokine release / D. Pagani, E. Galliera, G. Dogliotti, M. De Bernardi di Valserra, S. Torretta, U. Solimene, M.M. Corsi, L. Pignataro. - In: ARCHIVES OF MEDICAL RESEARCH. - ISSN 0188-4409. - 42:4(2011 May), pp. 329-333.
| Titolo: | Carbon dioxide-enriched water inhalation in patients with allergic rhinitis and its relationship with nasal fluid cytokine/chemokine release | |
| Autori: | GALLIERA, EMANUELA RITA (Secondo) PIGNATARO, LORENZO (Ultimo) | |
| Parole Chiave: | Allergic rhinitis; Chemokine; Cytokine; Carbon dioxide-enriched water inhalation | |
| Settore Scientifico Disciplinare: | Settore MED/31 - Otorinolaringoiatria Settore MED/05 - Patologia Clinica | |
| Data di pubblicazione: | mag-2011 | |
| Rivista: | ||
| Tipologia: | Article (author) | |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/j.arcmed.2011.07.001 | |
| Appare nelle tipologie: | 01 - Articolo su periodico |
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