Background and Aims: Allergic rhinitis is characterized by eosinophil infiltration and accumulation in the nasal mucosa mainly due to IL-3, IL-5, and eotaxin activities. We undertook this study to investigate a possible in vivo effect of carbon dioxide-enriched water inhalation in patients with allergic rhinitis. Methods: Twenty five consecutive patients inhaled carbon dioxide-enriched water at Fonti di Rabbi Spa Centre (Trento, Italy). Symptom scores for nasal obstruction, itching and sneezing were obtained before and after treatment. Nasal lavage was collected, and IL-3, IL-5, and eotaxin levels were assessed using the quantitative sandwich enzyme immunoassay technique. Cytometric analysis was performed on samples to measure total cell count, CD45+ cells, and percentages of polymorphonucleates and lymphocytes. Results: There were statistically significant differences in chemokine levels and in cell populations between patients and healthy controls before treatment. After carbon dioxide-enriched water inhalation, we observed statistically significant improvements in symptom scores, chemokine levels, and percentages of cell populations. Conclusions: Our results seem to confirm the role of IL-3, IL-5, and eotaxin in the pathophysiology of allergy and the beneficial effect of carbon dioxide-enriched water inhalation in patients affected by allergic rhinitis.
Carbon dioxide-enriched water inhalation in patients with allergic rhinitis and its relationship with nasal fluid cytokine/chemokine release / D. Pagani, E. Galliera, G. Dogliotti, M. De Bernardi di Valserra, S. Torretta, U. Solimene, M.M. Corsi, L. Pignataro. - In: ARCHIVES OF MEDICAL RESEARCH. - ISSN 0188-4409. - 42:4(2011 May), pp. 329-333.
|Titolo:||Carbon dioxide-enriched water inhalation in patients with allergic rhinitis and its relationship with nasal fluid cytokine/chemokine release|
GALLIERA, EMANUELA RITA (Secondo)
PIGNATARO, LORENZO (Ultimo)
|Parole Chiave:||Allergic rhinitis; Chemokine; Cytokine; Carbon dioxide-enriched water inhalation|
|Settore Scientifico Disciplinare:||Settore MED/31 - Otorinolaringoiatria|
Settore MED/05 - Patologia Clinica
|Data di pubblicazione:||mag-2011|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.arcmed.2011.07.001|
|Appare nelle tipologie:||01 - Articolo su periodico|