BACKGROUND AND METHODS: Portal vein thrombosis (PVT) has been reported as a complication of IBD in some case reports. We describe the presentation, diagnostic approaches, underlying risks factors and clinical outcome of 8 IBD patients with PVT. CASE-SERIES: The patients presented with partial PVT (4 patients) or portal cavernoma. Five patients had undergone surgery. In 2 patients portal biliopathy was diagnosed after detection of PVT. In 4 patients, the diagnosis of PVT was made while IBD was in remission. Five patients showed at least one risk factor for hypercoagulability: lupus anti-coagulant (one patient), increased von Willebrand factor (2 patients) or homocysteine levels (4 patients). Four patients received anticoagulant therapy for 6 months. None experienced other thrombotic events during a median of 5 years (range 2-8 years). CONCLUSION: PVT is a potential complication of IBD, usually associated with acquired or inherited risks factors for hypercoagulability and with a benign outcome.

Portal vein thrombosis in inflammatory bowel diseases : a single-center case series / G. Maconi, E. Bolzacchini, A. Dell’Era, U. Russo, S. Ardizzone, R. De Franchis. - In: JOURNAL OF CROHN'S AND COLITIS. - ISSN 1873-9946. - 6:3(2012), pp. 362-367.

Portal vein thrombosis in inflammatory bowel diseases : a single-center case series

G. Maconi;A. Dell’Era;S. Ardizzone;R. De Franchis
2012

Abstract

BACKGROUND AND METHODS: Portal vein thrombosis (PVT) has been reported as a complication of IBD in some case reports. We describe the presentation, diagnostic approaches, underlying risks factors and clinical outcome of 8 IBD patients with PVT. CASE-SERIES: The patients presented with partial PVT (4 patients) or portal cavernoma. Five patients had undergone surgery. In 2 patients portal biliopathy was diagnosed after detection of PVT. In 4 patients, the diagnosis of PVT was made while IBD was in remission. Five patients showed at least one risk factor for hypercoagulability: lupus anti-coagulant (one patient), increased von Willebrand factor (2 patients) or homocysteine levels (4 patients). Four patients received anticoagulant therapy for 6 months. None experienced other thrombotic events during a median of 5 years (range 2-8 years). CONCLUSION: PVT is a potential complication of IBD, usually associated with acquired or inherited risks factors for hypercoagulability and with a benign outcome.
Crohn's disease; inflammatory bowel diseases; portal cavernoma; portal vein thrombosis; ulcerative colitis
Settore MED/12 - Gastroenterologia
10-nov-2011
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/179383
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