BACKGROUND AND METHODS: Portal vein thrombosis (PVT) has been reported as a complication of IBD in some case reports. We describe the presentation, diagnostic approaches, underlying risks factors and clinical outcome of 8 IBD patients with PVT. CASE-SERIES: The patients presented with partial PVT (4 patients) or portal cavernoma. Five patients had undergone surgery. In 2 patients portal biliopathy was diagnosed after detection of PVT. In 4 patients, the diagnosis of PVT was made while IBD was in remission. Five patients showed at least one risk factor for hypercoagulability: lupus anti-coagulant (one patient), increased von Willebrand factor (2 patients) or homocysteine levels (4 patients). Four patients received anticoagulant therapy for 6 months. None experienced other thrombotic events during a median of 5 years (range 2-8 years). CONCLUSION: PVT is a potential complication of IBD, usually associated with acquired or inherited risks factors for hypercoagulability and with a benign outcome.
|Titolo:||Portal vein thrombosis in inflammatory bowel diseases : a single-center case series|
|Parole Chiave:||Crohn's disease; inflammatory bowel diseases; portal cavernoma; portal vein thrombosis; ulcerative colitis|
|Settore Scientifico Disciplinare:||Settore MED/12 - Gastroenterologia|
|Data di pubblicazione:||2012|
|Data ahead of print / Data di stampa:||10-nov-2011|
|Digital Object Identifier (DOI):||10.1016/j.crohns.2011.10.003|
|Appare nelle tipologie:||01 - Articolo su periodico|