Multiple sclerosis (MS) varies considerably in its incidence and progression in females and males. In spite of clinical evidence, relatively few studies have explored molecular mechanisms possibly involved in gender-related differences. The present study describes possible cellular- and molecular-involved markers which are differentially regulated in male and female rats and result in gender-dependent EAE evolution and progression. Attention was focused on markers of myelination (MBP and PDGFαR) and neuronal distress and/or damage (GABA synthesis enzymes, GAD65 and GAD67, NGF, BDNF and related receptors), in two CNS areas, i.e. spinal cord and cerebellum, which are respectively severely and mildly affected by inflammation and demyelination. Tissues were sampled during acute, relapse/remission and chronic phases and results were analysed by two-way ANOVA.

Gender effect on neurodegeneration and myelin markers in an animal model for multiple sclerosis / A. Massella, G. D'Intino, M. Fernández, S. Sivilia, L. Lorenzini, S. Giatti, R.C. Melcangi, L. Calzà, L. Giardino. - In: BMC NEUROSCIENCE. - ISSN 1471-2202. - 13:1(2012), pp. 12.12.1-12.12.14.

Gender effect on neurodegeneration and myelin markers in an animal model for multiple sclerosis

S. Giatti;R.C. Melcangi;
2012

Abstract

Multiple sclerosis (MS) varies considerably in its incidence and progression in females and males. In spite of clinical evidence, relatively few studies have explored molecular mechanisms possibly involved in gender-related differences. The present study describes possible cellular- and molecular-involved markers which are differentially regulated in male and female rats and result in gender-dependent EAE evolution and progression. Attention was focused on markers of myelination (MBP and PDGFαR) and neuronal distress and/or damage (GABA synthesis enzymes, GAD65 and GAD67, NGF, BDNF and related receptors), in two CNS areas, i.e. spinal cord and cerebellum, which are respectively severely and mildly affected by inflammation and demyelination. Tissues were sampled during acute, relapse/remission and chronic phases and results were analysed by two-way ANOVA.
Myelin Basic Proteins ; Animals ; Analysis of Variance ; Spinal Cord ; Sex Characteristics ; Cerebellum ; Disease Models, Animal ; Polysaccharides ; Neurodegenerative Diseases ; Nerve Tissue Proteins ; Rats ; RNA, Messenger ; Multiple Sclerosis; Receptor, Platelet-Derived Growth Factor alpha ; Glutamate Decarboxylase ; Freund's Adjuvant ; Gene Expression Regulation ; Female ; Male
Settore MED/13 - Endocrinologia
Article (author)
File in questo prodotto:
File Dimensione Formato  
1471-2202-13-12.pdf

accesso aperto

Tipologia: Publisher's version/PDF
Dimensione 5.11 MB
Formato Adobe PDF
5.11 MB Adobe PDF Visualizza/Apri
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/178830
Citazioni
  • ???jsp.display-item.citation.pmc??? 7
  • Scopus 30
  • ???jsp.display-item.citation.isi??? 29
social impact