In this article, we offer an overview of the compared quantitative importance of biotransformation reactions in the metabolism of drugs and other xenobiotics, based on a meta-analysis of current research interests. Also, we assess the relative significance the enzyme (super)families or categories catalysing these reactions. We put the facts unveiled by the analysis into a drug discovery context and draw some implications. The results confirm the primary role of cytochrome P450-catalysed oxidations and UDP-glucuronosyl-catalysed glucuronidations, but they also document the marked significance of several other reactions. Thus, there is a need for several drug discovery scientists to better grasp the variety of drug metabolism reactions and enzymes and their consequences.
Reactions and enzymes in the metabolism of drugs and other xenobiotics / B. Testa, A. Pedretti, G. Vistoli. - In: DRUG DISCOVERY TODAY. - ISSN 1359-6446. - 17:11/12(2012 Jun), pp. 549-560.
|Titolo:||Reactions and enzymes in the metabolism of drugs and other xenobiotics|
PEDRETTI, ALESSANDRO (Secondo)
VISTOLI, GIULIO (Ultimo)
|Parole Chiave:||matabolism; meta-analysis; classification of metabolic reactions|
|Settore Scientifico Disciplinare:||Settore CHIM/08 - Chimica Farmaceutica|
|Data di pubblicazione:||giu-2012|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.drudis.2012.01.017|
|Appare nelle tipologie:||01 - Articolo su periodico|