TREX1 (three prime repair exonuclease 1) degrades excess HIV-1 DNA thereby preventing recognition by innate immunity receptors and type I interferon responses. Analyses performed in two HIV-exposed seronegative (HESN) cohorts did not show any differences in TREX1 sequence, SNPs frequency, or expression in HESN compared to controls, suggesting that - despite its central role in the HIV-1 infection process- genetic diversity at TREX1 is not a major determinant of susceptibility to infection in humans.

Genetic variability at the TREX1 locus is not associated with natural resistance to HIV-1 infection / M. Sironi, M. Biasin, D. Forni, R. Cagliani, M. de Luca, I. Saulle, S.L. Caputo, F. Mazzotta, J. Macias, J.A. Pineda, A. Caruz, M. Clerici. - In: AIDS. - ISSN 0269-9370. - 26:11(2012 Jul 17), pp. 1443-1445. [10.1097/QAD.0b013e328354b3c2]

Genetic variability at the TREX1 locus is not associated with natural resistance to HIV-1 infection

M. Biasin;M. de Luca;I. Saulle;M. Clerici
2012-07-17

Abstract

TREX1 (three prime repair exonuclease 1) degrades excess HIV-1 DNA thereby preventing recognition by innate immunity receptors and type I interferon responses. Analyses performed in two HIV-exposed seronegative (HESN) cohorts did not show any differences in TREX1 sequence, SNPs frequency, or expression in HESN compared to controls, suggesting that - despite its central role in the HIV-1 infection process- genetic diversity at TREX1 is not a major determinant of susceptibility to infection in humans.
EXONUCLEASE TREX1 ; SERONEGATIVE INDIVIDUALS
Settore MED/04 - Patologia Generale
Settore BIO/13 - Biologia Applicata
AIDS
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/178122
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