HD-PTP (PTPN23) is a non-transmembrane protein tyrosine phosphatase which contributes to the signal transduction pathways involved in the regulation of cell migration and invasion. We here demonstrate in T24 bladder carcinoma cells that HD-PTP undergoes calcium-dependent degradation which can be prevented by specific calpain inhibitors. In addition, treatment of the cells with the calpain inhibitor calpeptin results in the redistribution of endogenous HD-PTP to the periphery of the cells. Since (i) calpains are overexpressed in some tumors and (ii) the downregulation of HD-PTP enhances cell migration and invasion, we propose that HD-PTP degradation by calpains might result in the acquisition of a more aggressive phenotype in neoplastic cells.
The tyrosine phosphatase HD-PTP (PTPN23) is degraded by calpains in a calcium-dependent manner / S. Castiglioni, J.A.M. MAier. - In: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. - ISSN 0006-291X. - 421:2(2012), pp. 380-383.
|Titolo:||The tyrosine phosphatase HD-PTP (PTPN23) is degraded by calpains in a calcium-dependent manner|
CASTIGLIONI, SARA (Primo)
MAIER, JEANETTE ANNE MARIE (Ultimo)
|Parole Chiave:||Calpains; HD-PTP; T24 bladder carcinoma cells|
|Settore Scientifico Disciplinare:||Settore MED/04 - Patologia Generale|
|Data di pubblicazione:||2012|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.bbrc.2012.04.024|
|Appare nelle tipologie:||01 - Articolo su periodico|