The uptake of [3H]dopamine was studied in the C cells of chicken ultimobranchial gland (UBG). DA uptake appears to be an active and saturable mechanism (K(m) = 8.6 μM). The C cells' affinity for DA is intermediate between dopaminergic synaptosomes and such extraneural tissues as platelets and heart. UBG incubation with DA leads to the synthesis of a noticeable quantity of DOPAC, indirectly showing the presence of MAO activity. Thus UBG C cells, besides having both an embryological derivation from the neural crest and some morphological aspects similar to synaptosomes, also possess an active uptake mechanism for a central neurotransmitter.
|Titolo:||Similarities between A.P.U.D. cells and monoaminergic neurons: evidence for a dopamine uptake mechanism in C cells of chicken ultimobranchial gland|
POPOLI, MAURIZIO (Secondo)
|Settore Scientifico Disciplinare:||Settore BIO/14 - Farmacologia|
|Data di pubblicazione:||1980|
|Digital Object Identifier (DOI):||10.1111/j.1471-4159.1980.tb11173.x|
|Appare nelle tipologie:||01 - Articolo su periodico|