The uptake of [3H]dopamine was studied in the C cells of chicken ultimobranchial gland (UBG). DA uptake appears to be an active and saturable mechanism (K(m) = 8.6 μM). The C cells' affinity for DA is intermediate between dopaminergic synaptosomes and such extraneural tissues as platelets and heart. UBG incubation with DA leads to the synthesis of a noticeable quantity of DOPAC, indirectly showing the presence of MAO activity. Thus UBG C cells, besides having both an embryological derivation from the neural crest and some morphological aspects similar to synaptosomes, also possess an active uptake mechanism for a central neurotransmitter.

Similarities between A.P.U.D. cells and monoaminergic neurons: evidence for a dopamine uptake mechanism in C cells of chicken ultimobranchial gland / A. Di Lauro, M. Popoli, G. Campanella, U. Avati. - In: JOURNAL OF NEUROCHEMISTRY. - ISSN 0022-3042. - 34:3(1980), pp. 504-511.

Similarities between A.P.U.D. cells and monoaminergic neurons: evidence for a dopamine uptake mechanism in C cells of chicken ultimobranchial gland

M. Popoli
Secondo
;
1980

Abstract

The uptake of [3H]dopamine was studied in the C cells of chicken ultimobranchial gland (UBG). DA uptake appears to be an active and saturable mechanism (K(m) = 8.6 μM). The C cells' affinity for DA is intermediate between dopaminergic synaptosomes and such extraneural tissues as platelets and heart. UBG incubation with DA leads to the synthesis of a noticeable quantity of DOPAC, indirectly showing the presence of MAO activity. Thus UBG C cells, besides having both an embryological derivation from the neural crest and some morphological aspects similar to synaptosomes, also possess an active uptake mechanism for a central neurotransmitter.
Settore BIO/14 - Farmacologia
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/177814
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