Oxazolo[5,4-b]pyridines 4 are synthesized by heating the iminophosphoranes 1 and alkylideneoxazol-5(4H)-ones 2. At room temperature the reaction of 4-ethoxymethyleneoxazol-5(4H)-one 2f with iminophosphorane 1a yields the enamino lactone 6, which is, in turn, transformed by heating in acetic acid into the 2(1H)-pyridone 7.
Oxazol-5(4H)-ones. Part 7. New synthesis of oxazolo[5,4-b]pyridines / M.L. Gelmi, D. Pocar, M. Viziano, R. Destro, F. Merati. - In: JOURNAL OF THE CHEMICAL SOCIETY. PERKIN TRANSACTIONS. I. - ISSN 0300-922X. - 1992:6(1992), pp. 701-705. [10.1039/P19920000701]
Oxazol-5(4H)-ones. Part 7. New synthesis of oxazolo[5,4-b]pyridines
M.L. GelmiPrimo
;D. PocarSecondo
;R. DestroPenultimo
;
1992
Abstract
Oxazolo[5,4-b]pyridines 4 are synthesized by heating the iminophosphoranes 1 and alkylideneoxazol-5(4H)-ones 2. At room temperature the reaction of 4-ethoxymethyleneoxazol-5(4H)-one 2f with iminophosphorane 1a yields the enamino lactone 6, which is, in turn, transformed by heating in acetic acid into the 2(1H)-pyridone 7.
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