We report the isolation and characterization of novel expressed sequences from the spinal muscular atrophy (SMA) region on human chromosome 5q13. Based on the sequence homology studies these cDNAs were grouped in four classes, one of which shows extensive homologies with the beta-glucuronidase (BG) gene, differing in exon arrangement. The other cDNAs do not show any strong homology with known DNA sequences.
IDENTIFICATION OF MULTIPLE TRANSCRIBED SEQUENCES FROM THE SPINAL MUSCULAR-ATROPHY REGION ON HUMAN-CHROMOSOME-5 / A. PIZZUTI, A. COLOSIMO, A. RATTI, F. CAPON, M. GENNARELLI, V. SILANI, C. GHEZZI, S. LOCICERO, G. CALABRESE, G. PALKA, G. SCARLATO, G. NOVELLI, B. DALLAPICCOLA. - In: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. - ISSN 0006-291X. - 206:1(1995), pp. 294-301.
IDENTIFICATION OF MULTIPLE TRANSCRIBED SEQUENCES FROM THE SPINAL MUSCULAR-ATROPHY REGION ON HUMAN-CHROMOSOME-5
A. RATTI;V. SILANI;
1995
Abstract
We report the isolation and characterization of novel expressed sequences from the spinal muscular atrophy (SMA) region on human chromosome 5q13. Based on the sequence homology studies these cDNAs were grouped in four classes, one of which shows extensive homologies with the beta-glucuronidase (BG) gene, differing in exon arrangement. The other cDNAs do not show any strong homology with known DNA sequences.
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