The effect of two anticholinergic drugs administered intracerebroventricularly on acquisition of an 8-arm radial maze task was examined in the rat. Increasing doses of atropine (1, 4.5, 22.5, 45 μg/rat) and pirenzepine (4.5, 15, 60, 90 μg/rat) significantly impaired performance in the working-memory components of the task. For both drugs this impairment was linearly related to the log of the administered doses and log-dose-response relationships were parallel. The regression lines calculated for each parameter for both drugs were parallel to each other, thus allowing us to calculate the potency of atropine versus pirenzepine: atropine was 5.4 times more potent than pirenzepine for correct arm entries, 10 times more potent for the number of errors and 4 times more potent for the total time taken to complete the task. The relevance of M1 and M2 subtype central acetylcholine receptors in cognitive processes is discussed.

Effect of centrally administered atropine and pirenzepine on radial arm maze performance in the rat / M. Sala, D. Braida, P. Calcaterra, M.P. Leone, F.A. Comotti, S. Gianola, E. Gori. - In: EUROPEAN JOURNAL OF PHARMACOLOGY. - ISSN 0014-2999. - 194:1(1991), pp. 45-49. [10.1016/0014-2999(91)90122-7]

Effect of centrally administered atropine and pirenzepine on radial arm maze performance in the rat

M. Sala;D. Braida;
1991

Abstract

The effect of two anticholinergic drugs administered intracerebroventricularly on acquisition of an 8-arm radial maze task was examined in the rat. Increasing doses of atropine (1, 4.5, 22.5, 45 μg/rat) and pirenzepine (4.5, 15, 60, 90 μg/rat) significantly impaired performance in the working-memory components of the task. For both drugs this impairment was linearly related to the log of the administered doses and log-dose-response relationships were parallel. The regression lines calculated for each parameter for both drugs were parallel to each other, thus allowing us to calculate the potency of atropine versus pirenzepine: atropine was 5.4 times more potent than pirenzepine for correct arm entries, 10 times more potent for the number of errors and 4 times more potent for the total time taken to complete the task. The relevance of M1 and M2 subtype central acetylcholine receptors in cognitive processes is discussed.
(Intracerebroventricular administration); Atropine; Pirenzepine; Radial maze
Settore BIO/14 - Farmacologia
EUROPEAN JOURNAL OF PHARMACOLOGY
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/176996
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