PGI2 plus very low dose of heparin was infused in 6 lambs connected for long term extracorporeal circulation with a membrane lung. Hemodynamic and hemostasis parameters were compared to those of a control group treated only with standard doses of heparin. PGI2 efficacy in inhibiting platelet aggregation and platelet fall was confirmed. A small platelet release, measured as antiheparin activity, was observed during all the by-pass, but did not influence platelet capacity of recovering when PGI2 effect dissolved. Heparin needed resulted less than a quarter of the quantity used for the control group. In our experimental conditions the hemodynamic changes were mainly limited to a decrease in diastolic blood pressure.

Effect of PGI2 infusion during long term extracorporeal circulation with membrane lung in sheep / L. Uziel, A. Agostoni, E. Pirovano, A. Pesenti, A. Pelizzola, L. Gattinoni, D. Galmarini. - In: INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS. - ISSN 0391-3988. - 4:3(1981 May), pp. 142-145.

Effect of PGI2 infusion during long term extracorporeal circulation with membrane lung in sheep

A. Agostoni;A. Pesenti;L. Gattinoni;
1981

Abstract

PGI2 plus very low dose of heparin was infused in 6 lambs connected for long term extracorporeal circulation with a membrane lung. Hemodynamic and hemostasis parameters were compared to those of a control group treated only with standard doses of heparin. PGI2 efficacy in inhibiting platelet aggregation and platelet fall was confirmed. A small platelet release, measured as antiheparin activity, was observed during all the by-pass, but did not influence platelet capacity of recovering when PGI2 effect dissolved. Heparin needed resulted less than a quarter of the quantity used for the control group. In our experimental conditions the hemodynamic changes were mainly limited to a decrease in diastolic blood pressure.
Drug therapy combination ; blood coagulation ; animals ; platelet aggregation ; blood platelets ; extracorporeal circulation ; sheep ; prostaglandins ; epoprostenol ; hemodynamics ; heparin
Settore MED/41 - Anestesiologia
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/176894
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