PGI2 plus very low dose of heparin was infused in 6 lambs connected for long term extracorporeal circulation with a membrane lung. Hemodynamic and hemostasis parameters were compared to those of a control group treated only with standard doses of heparin. PGI2 efficacy in inhibiting platelet aggregation and platelet fall was confirmed. A small platelet release, measured as antiheparin activity, was observed during all the by-pass, but did not influence platelet capacity of recovering when PGI2 effect dissolved. Heparin needed resulted less than a quarter of the quantity used for the control group. In our experimental conditions the hemodynamic changes were mainly limited to a decrease in diastolic blood pressure.
|Titolo:||Effect of PGI2 infusion during long term extracorporeal circulation with membrane lung in sheep|
|Parole Chiave:||Drug therapy combination ; blood coagulation ; animals ; platelet aggregation ; blood platelets ; extracorporeal circulation ; sheep ; prostaglandins ; epoprostenol ; hemodynamics ; heparin|
|Settore Scientifico Disciplinare:||Settore MED/41 - Anestesiologia|
|Data di pubblicazione:||mag-1981|
|Appare nelle tipologie:||01 - Articolo su periodico|