To evaluate if circulatory and respiratory effects due to Platelet Activating Factor (PAF) administration are modulated by releasing of endogenous nitric oxide (NO), in six anesthetized, paralyzed and mechanically ventilated Large White pigs L-NAME (10 mg/kg iv), an inhibitor of NO synthase, was used. PAF (50 ng/kg iv) in control conditions caused bronchoconstriction, evidenced by an increase in resistances and elastances of the respiratory system, pulmonary hypertension and a transient systemic hypotension. L-NAME, administered in control conditions, caused an increase in systemic and pulmonary arterial pressure and a modest increase in resistances and elastances of the respiratory system. After PAF, L-NAME caused strengthened bronchoconstriction and pulmonary hypertension, without modifying systemic hypotension. These results show that endogenous NO counterbalances respiratory and pulmonary vascular effects of PAF, while it is not involved in the systemic hypotension PAF-dependent.

Effetti vascolari e respiratori della NG-Nitro-L-arginina metil estere (L-NAME), inibitore della NO sintasi / M. Albertini. - In: ATTI DELLA SOCIETA' ITALIANA DELLE SCIENZE VETERINARIE. - ISSN 1721-1980. - 48:(1994), pp. 195-199. ((Intervento presentato al 48. convegno Convegno nazionale SISVet tenutosi a Giardini Naxos nel 1994.

Effetti vascolari e respiratori della NG-Nitro-L-arginina metil estere (L-NAME), inibitore della NO sintasi

M. Albertini
Primo
1994

Abstract

To evaluate if circulatory and respiratory effects due to Platelet Activating Factor (PAF) administration are modulated by releasing of endogenous nitric oxide (NO), in six anesthetized, paralyzed and mechanically ventilated Large White pigs L-NAME (10 mg/kg iv), an inhibitor of NO synthase, was used. PAF (50 ng/kg iv) in control conditions caused bronchoconstriction, evidenced by an increase in resistances and elastances of the respiratory system, pulmonary hypertension and a transient systemic hypotension. L-NAME, administered in control conditions, caused an increase in systemic and pulmonary arterial pressure and a modest increase in resistances and elastances of the respiratory system. After PAF, L-NAME caused strengthened bronchoconstriction and pulmonary hypertension, without modifying systemic hypotension. These results show that endogenous NO counterbalances respiratory and pulmonary vascular effects of PAF, while it is not involved in the systemic hypotension PAF-dependent.
Settore VET/02 - Fisiologia Veterinaria
Società italiana delle scienze veterinarie
SISVet
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/176771
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