Background. Outcomes of split-liver transplantation (SLT) with pediatric donors have never been specifically reported. Methods. A prospective multicenter study on SLT using donors younger than 15 years was conducted. Thirty-nine split-liver procedures generating a left lateral segment (LLS) and an extended right graft (ERG) were performed. In three cases, no recipient was found for ERG. In all but one case, the celiac trunk was maintained with LLS. Data were available for 67 grafts (90% of the total): 38 LLSs and 9 ERGs transplanted into 46 children and 20 ERGs transplanted into 20 adults. Sixty-two (93%) grafts were used for primary transplants and five (7%) for retransplantation. SLT were performed with 15 donors 10 years of age and less and with 24 between 11 and 15 years. Results. Median follow-up was 24 months. Two-year patient and graft survival were 87% and 82%. Patient and graft survivals were not significantly different between pediatric and adult recipients, between recipients from donors 10 years of age and less and those between 11 and 15 years, and between recipients of LLS and ERG. Arterial complications occurred in 6% of cases (8% in the ≤10 year donors group, 5% in the 11-15 year donors group). The incidence of other complications was similar between groups. Conclusions. SLT with pediatric donors, even younger than 10 years, provided results comparable with those achievable using adult donors. The similar incidence of arterial complications among patients receiving LLS or ERG suggests that maintenance of the celiac trunk with LLS is not detrimental for right-sided grafts. Copyright
Split-liver transplantation with pediatric donors: a multicentre experience. / M. Cescon, M. Spada, M. Colledan, E. Adorno, U. valente, G. Rossi, P. Reggiani, G.L. Grazi, G. Tisone, P. Majno, X Rogiers, M. L. Santamaria, U. Baccarani, G.M. Ettorre, U. Cillo, M. Rossi, M. Scalamogna, B. Gridelli. - In: TRANSPLANTATION. - ISSN 0041-1337. - 79:9(2005), pp. 1148-1153.
Split-liver transplantation with pediatric donors: a multicentre experience.
G. Rossi;
2005
Abstract
Background. Outcomes of split-liver transplantation (SLT) with pediatric donors have never been specifically reported. Methods. A prospective multicenter study on SLT using donors younger than 15 years was conducted. Thirty-nine split-liver procedures generating a left lateral segment (LLS) and an extended right graft (ERG) were performed. In three cases, no recipient was found for ERG. In all but one case, the celiac trunk was maintained with LLS. Data were available for 67 grafts (90% of the total): 38 LLSs and 9 ERGs transplanted into 46 children and 20 ERGs transplanted into 20 adults. Sixty-two (93%) grafts were used for primary transplants and five (7%) for retransplantation. SLT were performed with 15 donors 10 years of age and less and with 24 between 11 and 15 years. Results. Median follow-up was 24 months. Two-year patient and graft survival were 87% and 82%. Patient and graft survivals were not significantly different between pediatric and adult recipients, between recipients from donors 10 years of age and less and those between 11 and 15 years, and between recipients of LLS and ERG. Arterial complications occurred in 6% of cases (8% in the ≤10 year donors group, 5% in the 11-15 year donors group). The incidence of other complications was similar between groups. Conclusions. SLT with pediatric donors, even younger than 10 years, provided results comparable with those achievable using adult donors. The similar incidence of arterial complications among patients receiving LLS or ERG suggests that maintenance of the celiac trunk with LLS is not detrimental for right-sided grafts. Copyright
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