The respiratory and vascular effects of Endothelin-1 (ET-1) were evaluated in six anesthetized and spontaneously breathing pigs. ET-1 was administered intrajugularly as a bolus of 100 pmol/Kg. Then the vascular effects of the peptide, administered at the same dose, were evaluated in the same pigs during mechanical ventilation. Our results show that during mechanical ventilation ET-1 has a biphasic effect on pulmonary and systemic arterial pressure, while in spontaneously breathing pigs it affects only pulmonary arterial pressure. Our results also show that ET-1 changes the breathing pattern, lengthening the inspiration and expiration times. During pulmonary hypertension, the lengthening might be due to a vagal reflex, while during pulmonary hypotension it might be due to direct involvement of ET-1 in the control of the breathing pattern.

Endothelin-1 and breathing pattern in pig / M.G. Clement, M. Albertini. - In: BIOMEDICAL RESEARCH. - ISSN 0970-938X. - 7:1(1996), pp. 27-33.

Endothelin-1 and breathing pattern in pig

M.G. Clement
Primo
;
M. Albertini
Ultimo
1996

Abstract

The respiratory and vascular effects of Endothelin-1 (ET-1) were evaluated in six anesthetized and spontaneously breathing pigs. ET-1 was administered intrajugularly as a bolus of 100 pmol/Kg. Then the vascular effects of the peptide, administered at the same dose, were evaluated in the same pigs during mechanical ventilation. Our results show that during mechanical ventilation ET-1 has a biphasic effect on pulmonary and systemic arterial pressure, while in spontaneously breathing pigs it affects only pulmonary arterial pressure. Our results also show that ET-1 changes the breathing pattern, lengthening the inspiration and expiration times. During pulmonary hypertension, the lengthening might be due to a vagal reflex, while during pulmonary hypotension it might be due to direct involvement of ET-1 in the control of the breathing pattern.
Settore VET/02 - Fisiologia Veterinaria
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/176682
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