In rodents, the Ras-specific guanine-nucleotide exchange factor (Ras-GRF) is expressed in different areas of the brain and, at a reduced level, also in the spinal cord. No expression of the 140 kDa Ras-GRF was detected in dorsal root ganglia and all other tissues tested. Analysis of primary cultures derived from brain reveals that this exchange factor is only present in neurons of the central nervous system. In primary hippocampal cultures, the expression of Ras-GRF increases in parallel with the onset of a neuronal network and in the whole brain it increases sharply after birth.
Ras-GRF, the activator of Ras, is expressed preferentially in mature neurons of the central nervous system / R. Zippel, N. Gnesutta, N. Matus-Leibovitch, E. Mancinelli, D. Saya, Z. Vogel, E. Sturani. - In: MOLECULAR BRAIN RESEARCH. - ISSN 0169-328X. - 48:1(1997), pp. 140-144.
Ras-GRF, the activator of Ras, is expressed preferentially in mature neurons of the central nervous system
R. ZippelPrimo
;N. GnesuttaSecondo
;E. Mancinelli;E. SturaniUltimo
1997
Abstract
In rodents, the Ras-specific guanine-nucleotide exchange factor (Ras-GRF) is expressed in different areas of the brain and, at a reduced level, also in the spinal cord. No expression of the 140 kDa Ras-GRF was detected in dorsal root ganglia and all other tissues tested. Analysis of primary cultures derived from brain reveals that this exchange factor is only present in neurons of the central nervous system. In primary hippocampal cultures, the expression of Ras-GRF increases in parallel with the onset of a neuronal network and in the whole brain it increases sharply after birth.Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.