Peptides of the bombesin family are mitogenic for Swiss 3T3 fibroblasts and in these cells stimulate the turnover of polyphosphoinositides. Recent studies have suggested that G protein(s) may be involved in the signal transduction pathway triggered by bombesin. In this study we have found and characterized a high affinity GTPase activity stimulated by bombesin in membranes of Swiss 3T3 fibroblasts. Our results support the involvement of a G protein in the response of Swiss 3T3 cells to bombesin.

Bombesin stimulates a high affinity GTPase activity in membranes of Swiss 3T3 fibroblasts / L. Morello, E. Sturani, M.G. Cattaneo, R. Brambilla, A. Vicario, L. Alberghina , R. Zippel. - In: BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH. - ISSN 0167-4889. - 1092:3(1991 May), pp. 397-400.

Bombesin stimulates a high affinity GTPase activity in membranes of Swiss 3T3 fibroblasts

M.G. Cattaneo;
1991

Abstract

Peptides of the bombesin family are mitogenic for Swiss 3T3 fibroblasts and in these cells stimulate the turnover of polyphosphoinositides. Recent studies have suggested that G protein(s) may be involved in the signal transduction pathway triggered by bombesin. In this study we have found and characterized a high affinity GTPase activity stimulated by bombesin in membranes of Swiss 3T3 fibroblasts. Our results support the involvement of a G protein in the response of Swiss 3T3 cells to bombesin.
Bombesin; G protein (Mouse fibroblast); GTPase
Settore BIO/14 - Farmacologia
mag-1991
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/176620
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