A proportion of patients with peripheral neuropathies has circulating autoantibodies directed against neural antigens. In some cases, autoantibodies may play a pathogenic role. We studied a patient with a progressive sensory-motor axonal neuropathy of unknown etiology, looking for circulating autoantibodies against neural antigens and we showed that the patient's serum contained anti-amphiphysin I (AMP I) and amphiphysin II (AMP II) autoantibodies. A sural nerve biopsy revealed an axonal neuropathy. Indirect immunofluorescence experiments with the patient's serum showed a staining of rat axons due to alpha-AMP I autoantibodies and a specific labelling of cytoplasm and Schmidt-Lanterman incisures of Schwann cells due to alpha-AMP II autoantibodies. In conclusion we identified a patient affected by a sensory-motor neuropathy with autoantibodies against both AMP I and AMP II.
Autoantibodies to amphiphysin I and amphiphysin II in a patient with sensory-motor neuropathy / L. Perego, S. C. Previtali, R. Nemni, R. Longhi, O. Carandente, A. Saibene, R. Sciolla, A. Villa, P. Gai, C. Panzeri, G. Dell'Antonio, A. Quattrini, F. Folli. - In: EUROPEAN NEUROLOGY. - ISSN 0014-3022. - 47:4(2002), pp. 196-200.
|Titolo:||Autoantibodies to amphiphysin I and amphiphysin II in a patient with sensory-motor neuropathy|
|Parole Chiave:||Hereditary Sensory and Autonomic Neuropathies ; Blotting, Western ; Autoantibodies ; Humans ; Neural Conduction ; Aged; Fluorescent Antibody Technique ; Nerve Tissue Proteins ; Male; Motor Neurons|
|Settore Scientifico Disciplinare:||Settore MED/26 - Neurologia|
|Data di pubblicazione:||2002|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1159/000057898|
|Appare nelle tipologie:||01 - Articolo su periodico|