The Maize diet used selectively lowers the tryptophan, serotonin and 5-hydroxyindoleacetic acid levels in the central nervous system without affecting catecholamine content. These changes are maximal as early as 48 hours after exposure to the Maize diet. The brain serotonin decrease is reversed to normal when the Maize diet is supplemented with Tryptophan, while nicotinic acid is ineffective. The maize diet seems to be a rapid and selective means of reducing brain serotonin content. The hypothesis that the psychic depression observed in patients with Pellagra may be related to an altered serotonin metabolism is discussed.

Selective effect of a maize diet in reducing serum and brain tryptophan contents and blood and brain serotonin levels / F. Zambotti, M. Carruba, L. Vicentini, P. Mantegazza. - In: LIFE SCIENCES. - ISSN 0024-3205. - 17:11(1975 Dec 01), pp. 1663-1669.

Selective effect of a maize diet in reducing serum and brain tryptophan contents and blood and brain serotonin levels

M. Carruba
Secondo
;
L. Vicentini
Penultimo
;
1975

Abstract

The Maize diet used selectively lowers the tryptophan, serotonin and 5-hydroxyindoleacetic acid levels in the central nervous system without affecting catecholamine content. These changes are maximal as early as 48 hours after exposure to the Maize diet. The brain serotonin decrease is reversed to normal when the Maize diet is supplemented with Tryptophan, while nicotinic acid is ineffective. The maize diet seems to be a rapid and selective means of reducing brain serotonin content. The hypothesis that the psychic depression observed in patients with Pellagra may be related to an altered serotonin metabolism is discussed.
Animals; Tryptophan; Hydroxyindoleacetic Acid; Spinal Cord; Brain; Tyrosine; Serotonin; Body Weight; Rats; Nicotinic Acids; Dopamine; Zea mays; Vitamins; Norepinephrine; Diet; Male
Settore BIO/14 - Farmacologia
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/176411
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