Particularly suitable: An N-terminal serine mutant of anti-HER2 scFv antibody was conjugated to polymer-coated magnetofluorescent nanoparticles by strain-promoted alkyne-nitrone cycloaddition. The resulting nanoparticles (see scheme) proved effective in targeting and labeling HER2-positive breast cancer cells. Copyright
Site-specific conjugation of ScFvs antibodies to nanoparticles by bioorthogonal strain-promoted alkyne-nitrone cycloaddition / M. Colombo, S. Sommaruga, S. Mazzucchelli, L. Polito, P. Verderio, P. Galeffi, F. Corsi, P. Tortora, D. Prosperi. - In: ANGEWANDTE CHEMIE. INTERNATIONAL EDITION. - ISSN 1433-7851. - 51:2(2012), pp. 496-499.
Titolo: | Site-specific conjugation of ScFvs antibodies to nanoparticles by bioorthogonal strain-promoted alkyne-nitrone cycloaddition |
Autori: | COLOMBO, MIRIAM (Primo) |
Parole Chiave: | bioorthogonal reaction; cell targeting; cycloaddition; nanoparticles; scFv antibody |
Settore Scientifico Disciplinare: | Settore MED/06 - Oncologia Medica Settore BIO/12 - Biochimica Clinica e Biologia Molecolare Clinica |
Data di pubblicazione: | 2012 |
Rivista: | |
Tipologia: | Article (author) |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1002/anie.201106775 |
Appare nelle tipologie: | 01 - Articolo su periodico |