Little is known about the relationship between fungicidal activity of isoflavonoid phytoalexins and their physicochemical properties, in particular partition properties. As a first part of an investigation on the influence of partition coefficients on the fungicidal activity of analogues of isoflavonoid phytoalexins, a series of 3-phenylcoumarins, including ethers and side-chain derivatives of high lipophilicity, were synthesized and tested in vitro and in vivo for antifungal activity. The results seem to indicate that an increase of lipophilicity has a negative effect and a free OH is indispensable for activity.
Analogs of phytoalexins. Synthesis of some 3-phenylcoumarins and their fungicidal activity / A. Arnoldi, G. Farina, R. Galli, L. Merlini, M.G. Parrino. - In: JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY. - ISSN 0021-8561. - 34:2(1986), pp. 185-188.
Analogs of phytoalexins. Synthesis of some 3-phenylcoumarins and their fungicidal activity
A. ArnoldiPrimo
;G. FarinaSecondo
;R. Galli;L. MerliniPenultimo
;
1986
Abstract
Little is known about the relationship between fungicidal activity of isoflavonoid phytoalexins and their physicochemical properties, in particular partition properties. As a first part of an investigation on the influence of partition coefficients on the fungicidal activity of analogues of isoflavonoid phytoalexins, a series of 3-phenylcoumarins, including ethers and side-chain derivatives of high lipophilicity, were synthesized and tested in vitro and in vivo for antifungal activity. The results seem to indicate that an increase of lipophilicity has a negative effect and a free OH is indispensable for activity.Pubblicazioni consigliate
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