Lipase-catalyzed transesterification of 2-methyl-1,3-propanediol 1 in chloroform affords enantiomerically pure (S)-(-)-acetate 2, from which the (R)-(+)-silyl ethers 4a-b can be efficiently prepared (>98% ee). The (S)-TBDPS derivative 4b could be also efficiently and enantioselectively prepared by the same enzymatic procedure, starting from racemic 5b.
An efficient chemo-enzymatic approach to the enantioselective synthesis of 2-methyl-1,3-propamedical derivatives / E. Santaniello, P. Ferraboschi, P. Grisenti. - In: TETRAHEDRON LETTERS. - ISSN 0040-4039. - 31:39(1990), pp. 5657-5660.
Titolo: | An efficient chemo-enzymatic approach to the enantioselective synthesis of 2-methyl-1,3-propamedical derivatives |
Autori: | SANTANIELLO, ENZO (Primo) FERRABOSCHI, PATRIZIA (Secondo) |
Settore Scientifico Disciplinare: | Settore BIO/10 - Biochimica |
Data di pubblicazione: | 1990 |
Rivista: | |
Tipologia: | Article (author) |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/S0040-4039(00)97925-5 |
Appare nelle tipologie: | 01 - Articolo su periodico |
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