A recently developed isoelectric focusing technique for human globin chain separation has been applied to the antenatal diagnosis of beta 0-thalassemia in Sardinia. Results obtained with this method show a complete concordance with those obtained by the currently-in-use chromatographic separation of globin chains by carboxymethyl-cellulose. The ease with which several samples (up to 20) can be simultaneously processed and analyzed by a single operator and the very simple equipment required make this new method ideal for the antenatal diagnosis of beta 0-thalassemia and could encourage a more widespread use of prenatal diagnosis of thalassemias
Isoelectric focusing of globin chains for antenatal diagnosis of beta 0-thalassemia / A.M. Gianni, E. Polli, B. Giglioni, P. Comi, S. Ottolenghi, M. Ferrari, M. Furbetta, A. Angius, A. Cao. - In: HEMOGLOBIN. - ISSN 0363-0269. - 5:4(1981), pp. 349-356.
Isoelectric focusing of globin chains for antenatal diagnosis of beta 0-thalassemia
A.M. Gianni;
1981
Abstract
A recently developed isoelectric focusing technique for human globin chain separation has been applied to the antenatal diagnosis of beta 0-thalassemia in Sardinia. Results obtained with this method show a complete concordance with those obtained by the currently-in-use chromatographic separation of globin chains by carboxymethyl-cellulose. The ease with which several samples (up to 20) can be simultaneously processed and analyzed by a single operator and the very simple equipment required make this new method ideal for the antenatal diagnosis of beta 0-thalassemia and could encourage a more widespread use of prenatal diagnosis of thalassemiasPubblicazioni consigliate
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