Glycerol 2,3-carbonate was resolved via Pseudomonas fluorescens lipase catalyzed acetylation of the racemate and subsequent alcoholysis of the optically enriched acetate product in the presence of the same enzyme. The two reactions, performed in CHCl3, gave (R)- and (S)-glycerol 2,3-carbonate respectively in high chemical and optical yields.
Lipase-catalyzed resolution of glycerol 2,3-carbonate / M. Pallavicini, E. Valoti, L. Villa, O. Piccolo. - In: JOURNAL OF ORGANIC CHEMISTRY. - ISSN 0022-3263. - 59:7(1994), pp. 1751-1754. [10.1021/jo00086a026]
Lipase-catalyzed resolution of glycerol 2,3-carbonate
M. PallaviciniPrimo
;E. ValotiSecondo
;
1994
Abstract
Glycerol 2,3-carbonate was resolved via Pseudomonas fluorescens lipase catalyzed acetylation of the racemate and subsequent alcoholysis of the optically enriched acetate product in the presence of the same enzyme. The two reactions, performed in CHCl3, gave (R)- and (S)-glycerol 2,3-carbonate respectively in high chemical and optical yields.
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