The degree of stereodifferentiation in the catalytic enantioselective reduction of some prochiral diethers of 1,3-dihydroxy-2-propanone was determined by high-performance liquid chromatography using the cellulose tris(3,5-dimethylphenylcarbamate) derivative Chiralcel OD as the chiral stationary phase. The method was validated and the analytical results evaluated with respect to the rotation values of the reduction products and those reported previously for the same intermediates prepared from chiral starting materials.
High-performance liquid chromatography determination of the enantiomeric excess of 1,3-glyceryl diethers obtained by stereoselective catalytic reduction / M. Pallavicini, L. Villa, E. Cesarotti. - In: JOURNAL OF CHROMATOGRAPHY A. - ISSN 0021-9673. - 604:2(1992), pp. 197-201. [10.1016/0021-9673(92)85128-G]
High-performance liquid chromatography determination of the enantiomeric excess of 1,3-glyceryl diethers obtained by stereoselective catalytic reduction
M. PallaviciniPrimo
;E. CesarottiUltimo
1992
Abstract
The degree of stereodifferentiation in the catalytic enantioselective reduction of some prochiral diethers of 1,3-dihydroxy-2-propanone was determined by high-performance liquid chromatography using the cellulose tris(3,5-dimethylphenylcarbamate) derivative Chiralcel OD as the chiral stationary phase. The method was validated and the analytical results evaluated with respect to the rotation values of the reduction products and those reported previously for the same intermediates prepared from chiral starting materials.
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