Amylin has been reported to have bone-conserving effects. In the present study we evaluated the possible activity of the peptide on human osteoblast-like (hOB) cells in primary culture. Amylin between 10(-9) and 10(-6) M, dose-dependently stimulated cell proliferation with a maximal effect (200%) at 10(-6) M. In addition, amylin increased osteocalcin production when hOB cells were exposed to 1,25(OH)2D3 (10(-8)M) but there was a nonsignificant upward trend on alkaline phosphatase activity. The present results suggest that amylin could be included among the group of peptides endowed with osteogenic activity.
Effects of amylin on human osteoblast-like cells / I. Villa, A. Rubinacci, F. Ravasi, A.F. Ferrara, F. Guidobono. - In: PEPTIDES. - ISSN 0196-9781. - 18:4(1997), pp. 537-540.
|Titolo:||Effects of amylin on human osteoblast-like cells|
GUIDOBONO CAVALCHINI, FRANCESCA (Ultimo)
|Parole Chiave:||Alkaline phosphatase; Amylin; Osteoblast-like cells; Osteocalcin; Proliferation|
|Settore Scientifico Disciplinare:||Settore BIO/14 - Farmacologia|
|Data di pubblicazione:||1997|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/S0196-9781(97)00056-9|
|Appare nelle tipologie:||01 - Articolo su periodico|