We hypothesized that redox analysis could provide sensitive markers of the oxidative pathway associated to the presence of an increasing number of cardiovascular risk factors (RFs), independently of type. We classified 304 subjects without cardiovascular disease into 4 groups according to the total number of RFs (smoking, hypertension, hypercholesterolaemia, hyperhomocysteinaemia, diabetes, obesity, and their combination). Oxidative stress was evaluated by measuring plasma total and reduced homocysteine, cysteine (Cys), glutathione, cysteinylglycine, blood reduced glutathione, and malondialdehyde. Twentyseven percent of subjects were in group 0 RF, 26% in 1 RF, 31% in 2 RF, and 16% in ≥3 RF. By multivariable ordinal regression analysis, plasma total Cys was associated to a higher number of RF (OR = 1.068; 95% CI = 1.027–1.110, P = 0.002). Total RF burden is associated with increased total Cys levels. These findings support a prooxidant effect of Cys in conjunction with RF burden, and shed light on the pathophysiologic role of redox state unbalance in preclinical atherosclerosis.
Plasma Total Cysteine and Cardiovascular Risk Burden : Action and Interaction / B. De Chiara, V. Sedda, M. Parolini, J. Campolo, R. De Maria, R. Caruso, G. Pizzi, O. Disoteo, C. Dellanoce, A.R. Corno, G.M. Cighetti, O. Parodi. - In: THE SCIENTIFIC WORLD JOURNAL. - ISSN 1537-744X. - (2012).
|Titolo:||Plasma Total Cysteine and Cardiovascular Risk Burden : Action and Interaction|
|Parole Chiave:||cardiovascular risk factors; lipid peroxidation; total plasma cysteine|
|Settore Scientifico Disciplinare:||Settore MED/11 - Malattie dell'Apparato Cardiovascolare|
|Data di pubblicazione:||2012|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1100/2012/303654|
|Appare nelle tipologie:||01 - Articolo su periodico|