A facile method for the synthesis of a series of new steroidal 3-thioxamides from the 3-oxo compound, variously substituted at the 17 position, is described. The ''one pot'' reaction, using Lawesson's reagent (4-methoxyphenylthionophosphine sulphide dimer) in dichloromethane solution, gives the desired compounds with a high degree of chemoselectivity, in good yields (>80%). (C) 1997 by Elsevier Science Inc.
A practical route for the synthesis of 17 substituted steroidal 3-thioxamides / P. Grisenti, A. Magni, A. Manzocchi, P. Ferraboschi. - In: STEROIDS. - ISSN 0039-128X. - 62:6(1997), pp. 504-506.
A practical route for the synthesis of 17 substituted steroidal 3-thioxamides
A. Manzocchi;P. Ferraboschi
1997
Abstract
A facile method for the synthesis of a series of new steroidal 3-thioxamides from the 3-oxo compound, variously substituted at the 17 position, is described. The ''one pot'' reaction, using Lawesson's reagent (4-methoxyphenylthionophosphine sulphide dimer) in dichloromethane solution, gives the desired compounds with a high degree of chemoselectivity, in good yields (>80%). (C) 1997 by Elsevier Science Inc.
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