A facile method for the synthesis of a series of new steroidal 3-thioxamides from the 3-oxo compound, variously substituted at the 17 position, is described. The ''one pot'' reaction, using Lawesson's reagent (4-methoxyphenylthionophosphine sulphide dimer) in dichloromethane solution, gives the desired compounds with a high degree of chemoselectivity, in good yields (>80%). (C) 1997 by Elsevier Science Inc.

A practical route for the synthesis of 17 substituted steroidal 3-thioxamides / P. Grisenti, A. Magni, A. Manzocchi, P. Ferraboschi. - In: STEROIDS. - ISSN 0039-128X. - 62:6(1997), pp. 504-506.

A practical route for the synthesis of 17 substituted steroidal 3-thioxamides

A. Manzocchi;P. Ferraboschi
1997

Abstract

A facile method for the synthesis of a series of new steroidal 3-thioxamides from the 3-oxo compound, variously substituted at the 17 position, is described. The ''one pot'' reaction, using Lawesson's reagent (4-methoxyphenylthionophosphine sulphide dimer) in dichloromethane solution, gives the desired compounds with a high degree of chemoselectivity, in good yields (>80%). (C) 1997 by Elsevier Science Inc.
3-oxo-4-azasteroids; 3-thioxo-4-azasteroids; Chemoselectivity; Lawesson's reagent; Testosterone 5-alpha reductase
Settore BIO/10 - Biochimica
STEROIDS
Article (author)
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/175693
Citazioni
  • ???jsp.display-item.citation.pmc??? 1
  • Scopus 5
  • ???jsp.display-item.citation.isi??? 5
social impact